Jan W. Drijfhout

Leiden University Medical Center — Netherlands

Immunology and Microbiology · Life Sciences

86h-index26.9kcitations398works1.22yr avg
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Research Topics

Immunotherapy and Immune Responses(134), Monoclonal and Polyclonal Antibodies Research(86), T-cell and B-cell Immunology(78), Immune Cell Function and Interaction(72), Antimicrobial Peptides and Activities(50)

Publications398 total

Branched tetrameric lactoferricin peptides modified with diaminopropionic acid exhibit potent antimicrobial and wound-healing activities
Frontiers in Pharmacology·2025Open Access
Machine Learning-Identified Potent Antimicrobial Peptides Against Multidrug-Resistant Bacteria and Skin Infections
Antibiotics·2025Open Access
Modulation of immunoglobulin G oligomerization by variable domain glycans: A mechanism to regulate complement activation
PNAS Nexus·2025Open Access
SAAP‐148 Oligomerizes into a Hexamer Forming a Hydrophobic Inner Core
ChemBioChem·2025· 2 citedOpen Access
Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement
Molecular Therapy Oncology·2025· 1 citedOpen Access
Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs
Blood Advances·2025· 8 citedOpen Access
Protease Specificity Profiling Using Synthetic Combinatorial Peptide Libraries and Mass Spectrometry
Methods in molecular biology·2025
Non‐prime‐ and prime‐side profiling of <scp>P</scp> ro‐ <scp>P</scp> ro endopeptidase specificity using synthetic combinatorial peptide libraries and mass spectrometry
FEBS Journal·2024· 1 citedOpen Access
Author response for "Non‐prime‐ and prime‐side profiling of &lt;scp&gt;P&lt;/scp&gt;ro‐&lt;scp&gt;P&lt;/scp&gt;ro endopeptidase specificity using synthetic combinatorial peptide libraries and mass spectrometry"
2024
Non-prime- and Prime-side Profiling of Pro-Pro Endopeptidase Specificity Using Synthetic Combinatorial Peptide Libraries and Mass Spectrometry
2024Open Access
Novel Antibacterial Agents SAAP-148 and Halicin Combat Gram-Negative Bacteria Colonizing Catheters
Antibiotics·2023· 6 citedOpen Access
Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation
Proceedings of the National Academy of Sciences·2023· 12 citedOpen Access
Encapsulation in oleyl-modified hyaluronic acid nanogels substantially improves the clinical potential of the antimicrobial peptides SAAP-148 and Ab-Cath
European Journal of Pharmaceutics and Biopharmaceutics·2023· 14 citedOpen Access
In-Depth Specificity Profiling of Endopeptidases Using Dedicated Mix-and-Split Synthetic Peptide Libraries and Mass Spectrometry
Analytical Chemistry·2023· 5 citedOpen Access
Bactericidal Activity to Escherichia coli: Different Modes of Action of Two 24-Mer Peptides SAAP-148 and OP-145, Both Derived from Human Cathelicidine LL-37
Antibiotics·2023· 8 citedOpen Access
Encapsulation into hyaluronic acid-based nanogels improves the selectivity index of the snake cathelicidin Ab-Cath
Nanomedicine Nanotechnology Biology and Medicine·2023· 10 citedOpen Access
Comparison of methods generating antibody-epitope conjugates for targeting cancer with virus-specific T cells
Frontiers in Immunology·2023· 7 citedOpen Access
CalcAMP: A New Machine Learning Model for the Accurate Prediction of Antimicrobial Activity of Peptides
Antibiotics·2023· 33 citedOpen Access
Supplementary Figure 1 from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy
2023Open Access
Supplementary Figure 1 from T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy
2023Open Access
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Frequent Co-authors

Sjoerd H. van der Burg(13), Peter A. van Veelen(13), Cornelis J.M. Melief(12), Frits Koning(10), Gemma G. Kenter(8), Rienk Offringa(8), Gert Jan Fleuren(7), Kees L. M. C. Franken(7), Marij J.P. Welters(6), Jaap Oostendorp(6), A. Rob P.M. Valentijn(5), Jeanette M. van der Hulst(5), Y Kooy(5), Ferry Ossendorp(5), Bart O. Roep(5), Dorien M. A. Berends-van der Meer(4), Annelies P.G. Vloon(4), Amon R. Wafelman(4), W. Martin Kast(4), Jacques Neefjes(4)