Y. Hsiou

Immunology and Microbiology · Life Sciences

13h-index2.2kcitations22works0.02yr avg
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Research Topics

HIV Research and Treatment(12), HIV/AIDS drug development and treatment(10), Biochemical and Molecular Research(6), Porphyrin and Phthalocyanine Chemistry(4), Metal complexes synthesis and properties(3)

Publications22 total

Structural Studies of HIV-1 Reverse Transcriptase and Implications for Drug Design
2018· 4 cited
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance
Journal of Molecular Biology·2001· 194 cited
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution
Journal of Molecular Biology·1998· 322 cited
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance 1 1Edited by J. Karn
Journal of Molecular Biology·1998· 123 cited
Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant
Journal of Molecular Biology·1996· 187 cited
TYR 181 CYS HIV-1 RT/8-CL TIBO
1996
Refined structure of HIV-1 reverse transcriptase complexed with a double-stranded DNA and an antibody Fab fragment at 2.8 Å resolution
Acta Crystallographica Section A Foundations of Crystallography·1996Open Access
Non-nucleoside RT inhibitors give HIV-1 RT a crooked back
Acta Crystallographica Section A Foundations of Crystallography·1996Open Access
Electron density averaging using multiple crystal forms or diffraction datasets in structure determination of protein at moderate resolution
Acta Crystallographica Section A Foundations of Crystallography·1996Open Access
Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms
Structure·1996· 285 citedOpen Access
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
1996
Targeting HIV reverse transcriptase for anti-AIDS drug design: structural and biological considerations for chemotherapeutic strategies.
PubMed·1996· 63 cited
Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.
Proceedings of the National Academy of Sciences·1996· 83 cited
Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates
Antimicrobial Agents and Chemotherapy·1995· 69 cited
Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution
Structure·1995· 209 citedOpen Access
Supramolecular architectures of functionalized tetraphenylmetalloporphyrins in crystalline solids. Studies of the 4-methoxyphenyl, 4-hydroxyphenyl and 4-chlorophenyl derivatives
Supramolecular chemistry·1994· 68 cited
Porphyrin sponges: conservative of host structure in over 200 porphyrin-based lattice clathrates
Journal of the American Chemical Society·1993· 382 cited
Porphyrin Sponges: Programmable Lattice Clathrates
Molecular crystals and liquid crystals science technology. Section A, Molecular crystals and liquid crystals/Molecular crystals and liquid crystals science and technology. Section A, Molecular crystals and liquid crystals·1992· 14 cited
Porphyrin sponges: structural systematics of the host lattice
Journal of the American Chemical Society·1991· 180 cited
Structures of tetracarbonyl(2–3-η-maleic acid)iron,<i>cis</i>-[Fe(C<sub>4</sub>H<sub>4</sub>O<sub>4</sub>)(CO)<sub>4</sub>] (1) and tetracarbonyl(2–3-η-fumaric acid)iron,<i>trans</i>-[Fe(C<sub>4</sub>H<sub>4</sub>O<sub>4</sub>)(CO)<sub>4</sub>] (2)
Acta Crystallographica Section C Crystal Structure Communications·1989· 9 cited
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Frequent Co-authors

Eddy Arnold(15), Kalyan Das(11), Jianping Ding(6), Stephen H. Hughes(5), Charles E. Strouse(4), Arthur D. Clark(4), Marianne P. Byrn(3), Carol J. Curtis(3), Saeed I. Khan(3), Philip A. Sawin(3), S. Kathleen Tendick(3), Alfredo Jacobo‐Molina(3), Paul L. Boyer(3), Manfred Rösner(3), S H Hughes(3), Chris Tantillo(2), AD Clark(2), Koen Andries(2), Rudi Pauwels(2), Henri Moereels(2)