S H Hughes

Frederick National Laboratory for Cancer Research — United States

Immunology and Microbiology · Life Sciences

24h-index3.5kcitations45works0.02yr avg
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Research Topics

HIV Research and Treatment(20), HIV/AIDS drug development and treatment(15), RNA and protein synthesis mechanisms(7), Biochemical and Molecular Research(7), Virus-based gene therapy research(6)

Publications45 total

Clones of HIV-infected cells are widely distributed in T cell subsets in blood and in anatomic tissues
Journal of Virus Eradication·2019Open Access
Crystal structure of ATPase domain of Human GRP78 bound to Ver155008
2018
Uncovering mechanisms of HIV persistence in HIV controllers by HIV sequence analysis in CD4 T cell subsets
Journal of Virus Eradication·2015· 1 citedOpen Access
Clones of SIV-infected cells are present in spleen and lymph nodes in rhesus macaques
Journal of Virus Eradication·2015· 2 citedOpen Access
HIV-1 Reverse Transcription
Cold Spring Harbor Perspectives in Medicine·2012· 458 citedOpen Access
Multiple Sources of Contamination in Samples from Patients Reported to Have XMRV Infection
PLoS ONE·2012· 50 citedOpen Access
CCDC 727856: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
Role of structures in designing anti-AIDS drugs targeting reverse transcriptase
Acta Crystallographica Section A Foundations of Crystallography·2008Open Access
Preparing recombinant proteins for X-ray crystallography
International Tables for Crystallography·2006· 1 cited
3. TECHNIQUES OF MOLECULAR BIOLOGY 3.1. Preparing recombinant proteins for X-ray crystallography
2006
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with JANSSEN-R165481
2005
X-ray structure for an RNase H inhibitor bound to HIV-1 reverse transcriptase
Acta Crystallographica Section A Foundations of Crystallography·2005· 1 citedOpen Access
Mutagenesis studies on recombinant human 11beta-hydroxysteroid dehydrogenase type 1
22nd Joint Meeting of the British Endocrine Societies·2003
Molecular modeling of HIV-1 reverse transcriptase drug-resistant mutant strains: implications for the mechanism of polymerase action
Protein Engineering Design and Selection·1997· 11 citedOpen Access
Expression of a murine leukemia virus Gag-Escherichia coli RNase HI fusion polyprotein significantly inhibits virus spread
Journal of Virology·1997· 13 citedOpen Access
Retroviral gene delivery.
PubMed·1997· 121 cited
Refined structure of HIV-1 reverse transcriptase complexed with a double-stranded DNA and an antibody Fab fragment at 2.8 Å resolution
Acta Crystallographica Section A Foundations of Crystallography·1996Open Access
Non-nucleoside RT inhibitors give HIV-1 RT a crooked back
Acta Crystallographica Section A Foundations of Crystallography·1996Open Access
Expression of transduced genes in mice generated by infecting blastocysts with avian leukosis virus-based retroviral vectors.
Proceedings of the National Academy of Sciences·1996· 39 citedOpen Access
Targeting HIV reverse transcriptase for anti-AIDS drug design: structural and biological considerations for chemotherapeutic strategies.
PubMed·1996· 63 cited
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Frequent Co-authors

Eddy Arnold(9), Amnon Hizi(6), Arthur D. Clark(5), Kalyan Das(5), Alfredo Jacobo‐Molina(4), Mark J. Federspiel(4), Raymond G. Nanni(3), Andrea L. Ferris(3), R. Tal(3), Y. Hsiou(3), Frank Maldarelli(3), Lu Xiao(2), Chris Tantillo(2), Greg Kamer(2), Yoel Kashman(2), Kirk R. Gustafson(2), James B. McMahon(2), Michael J. Currens(2), Robert W. Buckheit(2), Gordon M. Cragg(2)