Dyann F. Wirth

Broad Institute — United States

Medicine · Health Sciences

81h-index20.2kcitations402works4.42yr avg
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Research Topics

Malaria Research and Control(246), Mosquito-borne diseases and control(127), Trypanosoma species research and implications(47), Research on Leishmaniasis Studies(40), Computational Drug Discovery Methods(37)

Publications402 total

Phenotypic assessment and genetic validation of <i>Plasmodium falciparum</i> molecular markers associated with malaria chemoprevention in Senegal
2025Open Access
Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in <i>Plasmodium</i> HSP90 Inhibitors
2025Open Access
Disruption of P. falciparum amino acid transporter elevates intracellular proline and induces resistance to Prolyl-tRNA synthetase inhibitors
Cell chemical biology·2025· 1 cited
Cellular and molecular basis of <i>Pf</i> Coronin function in artemisinin resistance in <i>Plasmodium falciparum</i>
2025· 1 citedOpen Access
Strengthening Capacity in High-Burden Malaria-Endemic Countries: A Strategic Analysis of Training Gaps and Blended Learning Solutions in National Malaria Control Programs
2025Open Access
The plasmepsin-piperaquine paradox persists in Plasmodium falciparum
PLoS Pathogens·2025· 1 citedOpen Access
RDT performance through high-throughput bead-based antigen detection during malaria school survey in Senegal
Frontiers in Parasitology·2025Open Access
In vivo screen of Plasmodium targets for mosquito-based malaria control
Nature·2025· 10 citedOpen Access
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining
npj Drug Discovery.·2025· 6 citedOpen Access
Loss of P. falciparum Amino Acid Transporter (ApiAT2) Increases Intracellular Proline and Confers Resistance to Prolyl-tRNA Synthetase Inhibitors
SSRN Electronic Journal·2025· 1 citedOpen Access
The Plasmepsin-Piperaquine Paradox Persists
2024Open Access
Systematic in vitro evolution in <i>Plasmodium falciparum</i> reveals key determinants of drug resistance
Science·2024· 18 citedOpen Access
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining
2024· 1 citedOpen Access
<i>MalKinID</i>: A classification model for identifying malaria parasite genealogical relationships using identity-by-descent
Genetics·2024· 5 citedOpen Access
MalKinID: A Likelihood-Based Model for Identifying Malaria Parasite Genealogical Relationships Using Identity-by-Descent
2024Open Access
Two decades of molecular surveillance in Senegal reveal rapid changes in known drug resistance mutations over time
Malaria Journal·2024· 10 citedOpen Access
Genotypic analysis of RTS,S/AS01E malaria vaccine efficacy against parasite infection as a function of dosage regimen and baseline malaria infection status in children aged 5–17 months in Ghana and Kenya: a longitudinal phase 2b randomised controlled trial
The Lancet Infectious Diseases·2024· 16 citedOpen Access
Evaluating the performance of Plasmodium falciparum genetic metrics for inferring National Malaria Control Programme reported incidence in Senegal
Malaria Journal·2024· 9 citedOpen Access
Artemisinin resistance mutations in <i>Pfcoronin</i> impede hemoglobin uptake
2023· 6 citedOpen Access
Baseline malaria infection status and RTS,S/AS01E malaria vaccine efficacy
2023Open Access
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Frequent Co-authors

Sarah K. Volkman(18), Daniel E. Neafsey(14), S. F. Schaffner(9), Pardis C. Sabeti(8), Amanda K. Lukens(8), Elizabeth A. Winzeler(8), Daouda Ndiaye(7), Roger C. Wiegand(7), Daniel L. Hartl(7), Rachel F. Daniels(7), Daniel J. Park(6), Selina Bopp(6), Danny A. Milner(5), Manoj T. Duraisingh(5), Yingyao Zhou(5), David A. Fidock(5), Wesley Wong(5), Bruce W. Birren(4), Johanna P. Daily(4), Omar Ndir(4)