Amanda K. Lukens

Broad Institute — United States

Medicine · Health Sciences

29h-index3.5kcitations67works3.92yr avg
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Research Topics

Malaria Research and Control(39), HIV/AIDS drug development and treatment(14), Computational Drug Discovery Methods(12), Mosquito-borne diseases and control(9), Synthesis and Catalytic Reactions(8)

Publications67 total

Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
Nature·2025Open Access
Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in <i>Plasmodium</i> HSP90 Inhibitors
2025Open Access
Disruption of P. falciparum amino acid transporter elevates intracellular proline and induces resistance to Prolyl-tRNA synthetase inhibitors
Cell chemical biology·2025· 1 cited
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining
npj Drug Discovery.·2025· 6 citedOpen Access
Loss of P. falciparum Amino Acid Transporter (ApiAT2) Increases Intracellular Proline and Confers Resistance to Prolyl-tRNA Synthetase Inhibitors
SSRN Electronic Journal·2025· 1 citedOpen Access
Systematic in vitro evolution in <i>Plasmodium falciparum</i> reveals key determinants of drug resistance
Science·2024· 18 citedOpen Access
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining
2024· 1 citedOpen Access
Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance
eLife·2023· 5 citedOpen Access
Author response: Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance
2023Open Access
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation
Nature Communications·2023· 25 citedOpen Access
Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance
Nature Communications·2022· 28 citedOpen Access
Collateral sensitivity as a strategy to suppress resistance emergence: the challenge of diverse evolutionary pathways
2022Open Access
Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance
Communications Biology·2022· 20 citedOpen Access
Prioritization of Molecular Targets for Antimalarial Drug Discovery
ACS Infectious Diseases·2021· 79 citedOpen Access
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
Cell chemical biology·2021· 76 citedOpen Access
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance
Cell chemical biology·2021· 27 citedOpen Access
MalDA, Accelerating Malaria Drug Discovery
Trends in Parasitology·2021· 114 citedOpen Access
Defining the Yeast Resistome through <i>in vitro</i> Evolution and Whole Genome Sequencing
2021· 4 citedOpen Access
Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections
Scientific Reports·2020Open Access
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model
Science Translational Medicine·2019· 36 citedOpen Access
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Frequent Co-authors

Dyann F. Wirth(46), Elizabeth A. Winzeler(20), Francisco‐Javier Gamo(15), David A. Fidock(15), Sabine Ottilie(13), Sarah K. Volkman(12), Daniel E. Neafsey(10), Roger C. Wiegand(10), S. F. Schaffner(9), Daouda Ndiaye(9), Tomoyo Sakata‐Kato(9), Madeline R. Luth(9), Pardis C. Sabeti(8), Daniel L. Hartl(8), Eva S. Istvan(8), Lee M(8), Daniel E. Goldberg(8), Ralph Mazitschek(8), Danny A. Milner(7), Manu Vanaerschot(7)