Eva S. Istvan

Washington University in St. Louis — United States

Medicine · Health Sciences

24h-index4.6kcitations47works6.12yr avg
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Research Topics

Malaria Research and Control(28), Computational Drug Discovery Methods(10), Mosquito-borne diseases and control(7), HIV/AIDS drug development and treatment(6), Drug Transport and Resistance Mechanisms(6)

Publications47 total

BPS2026 – Helix-loop-helix domain facilitates protein targeting to membrane contact sites at the malaria parasite–host red blood cell interface
Biophysical Journal·2026
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining
npj Drug Discovery.·2025· 6 citedOpen Access
The <i>Plasmodium falciparum</i> NCR1 transporter is an antimalarial target that exports cholesterol from the parasite’s plasma membrane
Science Advances·2024· 4 citedOpen Access
Systematic in vitro evolution in <i>Plasmodium falciparum</i> reveals key determinants of drug resistance
Science·2024· 18 citedOpen Access
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining
2024· 1 citedOpen Access
The Plasmodium falciparum NCR1 membrane protein is a novel antimalarial target that exports cholesterol to maintain membrane homeostasis
2024
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase
Nature Communications·2024· 14 citedOpen Access
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase
Research Square (Research Square)·2023· 2 citedOpen Access
Human Polo-like Kinase Inhibitors as Antiplasmodials
ACS Infectious Diseases·2023· 8 citedOpen Access
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target
Science Translational Medicine·2023· 26 citedOpen Access
Prioritization of Molecular Targets for Antimalarial Drug Discovery
ACS Infectious Diseases·2021· 79 citedOpen Access
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance
Cell chemical biology·2021· 27 citedOpen Access
PfMFR3: A Multidrug-Resistant Modulator in <i>Plasmodium falciparum</i>
ACS Infectious Diseases·2021· 20 citedOpen Access
MalDA, Accelerating Malaria Drug Discovery
Trends in Parasitology·2021· 114 citedOpen Access
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
Nature Communications·2021· 91 citedOpen Access
Contacting domains segregate a lipid transporter from a solute transporter in the malarial host–parasite interface
Nature Communications·2020· 30 citedOpen Access
Malaria parasite plasmepsins: More than just plain old degradative pepsins
Journal of Biological Chemistry·2020· 93 citedOpen Access
Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery
Cell chemical biology·2019· 88 citedOpen Access
Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis
eLife·2019· 71 citedOpen Access
Author response: Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis
2019· 1 citedOpen Access
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Frequent Co-authors

Daniel E. Goldberg(31), Elizabeth A. Winzeler(22), Lee M(13), David A. Fidock(13), Jacquin C. Niles(12), Manuel Llinás(11), Sabine Ottilie(10), Francisco‐Javier Gamo(10), Amanda K. Lukens(9), Dyann F. Wirth(9), J. Deisenhofer(8), Edward Owen(7), Marı́a G. Gómez-Lorenzo(6), John Okombo(6), Krittikorn Kümpornsin(6), Madeline R. Luth(6), Manu Vanaerschot(5), Tomoyo Sakata‐Kato(5), Selina Bopp(5), Case W. McNamara(5)