Patricia Alfonso

Institute of Micro and Nanotechnology — Spain

Medicine · Health Sciences

18h-index1.1kcitations42works1.22yr avg
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Research Topics

Celiac Disease Research and Management(11), PI3K/AKT/mTOR signaling in cancer(8), Chronic Lymphocytic Leukemia Research(7), Cellular Mechanics and Interactions(4), Advanced Proteomics Techniques and Applications(4)

Publications42 total

An Assessment of Kinase Selectivity, Enzyme Inhibition Kinetics and in Vitro Activity for Several Bruton Tyrosine Kinase (BTK) Inhibitors
ACS Pharmacology & Translational Science·2025Open Access
Modulating the Binding Kinetics of Bruton’s Tyrosine Kinase Inhibitors through Transition-State Effects
Journal of the American Chemical Society·2025· 2 citedOpen Access
Covalent Targeting Leads to the Development of a LIMK1 Isoform-Selective Inhibitor
Journal of Medicinal Chemistry·2025· 2 citedOpen Access
Covalent targeting leads to the development of LIMK1 isoform-selective inhibitors
2025Open Access
Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor
ACS Chemical Biology·2025· 1 citedOpen Access
Repurposing of the RIPK1 selective benzo[1,4]oxazepin-4-one scaffold for the development of a type-III LIMK1/2 inhibitor
2025· 2 citedOpen Access
Discovery of Novel Bruton’s Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy
Journal of Medicinal Chemistry·2023· 12 citedOpen Access
Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases
Journal of Medicinal Chemistry·2023· 39 citedOpen Access
Synthesis and Preclinical Evaluation of a Novel Fluorine-18-Labeled Tracer for Positron Emission Tomography Imaging of Bruton’s Tyrosine Kinase
ACS Pharmacology & Translational Science·2023· 5 citedOpen Access
Potential use of carvacrol and citral to inactivate biofilm cells and eliminate biofouling
Food Control·2017· 43 cited
Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy
Bioorganic & Medicinal Chemistry Letters·2017· 10 citedOpen Access
Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR
Bioorganic & Medicinal Chemistry Letters·2012· 19 citedOpen Access
Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor
Bioorganic & Medicinal Chemistry Letters·2012· 22 citedOpen Access
Imidazo[1,2-a]pyrazines as novel PI3K inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 31 citedOpen Access
Abstract 627: Etp-47187 a novel potent and efficacious dual inhibitor of phosphoinositide-3-kinases and mTOR
Cancer Research·2011
Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition
Cancer Letters·2010· 62 cited
Chemical Interrogation of FOXO3a Nuclear Translocation Identifies Potent and Selective Inhibitors of Phosphoinositide 3-Kinases
Journal of Biological Chemistry·2009· 79 citedOpen Access
Proteome Analysis of Membrane Fractions in Colorectal Carcinomas by Using 2D-DIGE Saturation Labeling
Journal of Proteome Research·2008· 78 cited
Cell signaling proteomics in colorectal cancer
Universidad de Córdoba Insitutional Repository (Universidad de Córdoba)·2008Open Access
A Proteomics Analysis of Cell Signaling Alterations in Colorectal Cancer
Molecular & Cellular Proteomics·2007· 95 citedOpen Access
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Frequent Co-authors

Emilio Camafeita(11), Ana Corrionero(10), J. Ignacio Casal(8), Enrique Méndez(7), James R. Bischoff(7), Antonio Núñez(6), María I. Albarrán(6), Jesús Fominaya(6), Ana Isabel Hernández(6), Joaquı́n Pastor(6), Eduardo Méndez(6), Julen Oyarzábal(5), Obdulia Rabal(5), Milagros Lorenzo(5), Sonia Martı́nez(5), Héctor Escobar(5), Wolfgang Link(4), Antonio Cebriá(4), Teresa G. Granda(4), Carmen Varela(4)