Carmen Varela

Spanish National Cancer Research Centre — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index274citations18works0.02yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(6), Quinazolinone synthesis and applications(6), Synthesis and Reactivity of Heterocycles(4), Synthesis and biological activity(3), Chronic Lymphocytic Leukemia Research(3)

Publications18 total

Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors
ACS Medicinal Chemistry Letters·2021· 12 citedOpen Access
Corrigendum to <’ Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors’ [Eur. J. Med. Chem. 211 (2021), 113109]
European Journal of Medicinal Chemistry·2021
Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors
European Journal of Medicinal Chemistry·2020· 21 citedOpen Access
Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas
Proceedings of the National Academy of Sciences·2020· 21 citedOpen Access
Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors
European Journal of Medicinal Chemistry·2019· 37 citedOpen Access
Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy
Bioorganic & Medicinal Chemistry Letters·2017· 10 citedOpen Access
Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR
Bioorganic & Medicinal Chemistry Letters·2012· 19 citedOpen Access
Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor
Bioorganic & Medicinal Chemistry Letters·2012· 22 citedOpen Access
Imidazo[1,2-a]pyrazines as novel PI3K inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 31 citedOpen Access
CCDC 766900: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
New use of bis(benzotriazolyl)-1,2-(dialkylamino)ethanes for the synthesis of 2-H-3-dialkylamino imidazo[1,2-a]pyrazine derivatives
Tetrahedron Letters·2011· 4 cited
Synthesis of [1,2,4]-triazolo[1,5-a]pyrimidines by Dimroth rearrangement of [1,2,4]-triazolo[4,3-a]pyrimidines: A theoretical and NMR study
Journal of Molecular Structure·2010· 26 cited
183 Amino-alkyl substituted fused imidazoles: potent, selective and orally bioavailable inhibitors of PI3K
European Journal of Cancer Supplements·2010
177 Amino-carbonyl substituted fused imidazoles: potent, selective and orally bioavailable inhibitors of PI3K
European Journal of Cancer Supplements·2010
Differentiation between [1,2,4]triazolo[1,5‐a] pyrimidine and [1,2,4]triazolo[4,3‐a]‐ pyrimidine regioisomers by <sup>1</sup>H<sup>15</sup>N HMBC experiments
Magnetic Resonance in Chemistry·2010· 32 cited
Heregulin-induced apoptosis
APOPTOSIS·2002· 22 cited
Synthesis of Tetracyclic Analogues of Calcitriol (1,25-Dihydroxyvitamin D3) with Side-Chain-Locked Spatial Orientations at C(20)
Helvetica Chimica Acta·2002· 17 cited
A New Route to the Vitamin D Triene System
1994

Frequent Co-authors

Sonia Martı́nez(10), Joaquı́n Pastor(10), María I. Albarrán(8), Julen Oyarzábal(7), David Cebrián(7), Ana Isabel Hernández(6), James R. Bischoff(6), Antonio Cebriá(6), Carmen Blanco‐Aparicio(6), Rosa M. Álvarez(6), Sonsoles Rodríguez-Arístegui(5), Esther González Cantalapiedra(5), Ana Belén Garcı́a(5), Obdulia Rabal(5), Milagros Lorenzo(5), Elena Gómez‐Casero(4), Antonio Salgado(4), Patricia Alfonso(4), Wolfgang Link(4), Jesús Fominaya(4)