Madhavika N. Serasinghe

Icahn School of Medicine at Mount Sinai — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.8kcitations26works0.02yr avg
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Research Topics

Mitochondrial Function and Pathology(9), ATP Synthase and ATPases Research(6), Cell death mechanisms and regulation(5), Ubiquitin and proteasome pathways(4), Melanoma and MAPK Pathways(4)

Publications26 total

A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAF <sup>V600E</sup> -Associated Mitochondrial Division in Cancer
2026Open Access
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
Cell stem cell·2022· 89 citedOpen Access
PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
2021· 1 citedOpen Access
Repeated hypoglycemia remodels neural inputs and disrupts mitochondrial function to blunt glucose-inhibited GHRH neuron responsiveness
JCI Insight·2020· 14 citedOpen Access
Cell death through the ages: The ICDS 25th Anniversary Meeting
FEBS Journal·2020Open Access
Repeated hypoglycemia blunts the responsiveness of glucose-inhibited GHRH neurons by remodeling neural inputs and disrupting mitochondrial structure and function
2019Open Access
MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network
Molecular Cell·2019· 75 citedOpen Access
Late-onset megaconial myopathy in mice lacking group I Paks
Skeletal Muscle·2019· 19 citedOpen Access
<scp>FBXW</scp>7 regulates a mitochondrial transcription program by modulating <scp>MITF</scp>
Pigment Cell & Melanoma Research·2018· 19 cited
Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition
Cell Death and Disease·2018· 30 citedOpen Access
RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions
The Journal of Experimental Medicine·2017· 79 citedOpen Access
Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition
Journal of Biological Chemistry·2017· 84 citedOpen Access
Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells
Nature·2017· 179 citedOpen Access
Mitochondrial Fission in Human Diseases
Handbook of experimental pharmacology·2016· 170 citedOpen Access
Mitochondrial metabolism in hematopoietic stem cells requires functional <scp>FOXO</scp> 3
EMBO Reports·2015· 148 citedOpen Access
From zero to sixty: cell death signaling in the city that never sleeps
Oncogene·2015Open Access
Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAFV600E Melanoma
Journal of Investigative Dermatology·2015· 60 citedOpen Access
Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors
Molecular Cell·2015· 387 citedOpen Access
Mitochondrial Shape Governs BAX-Induced Membrane Permeabilization and Apoptosis
Molecular Cell·2014· 214 citedOpen Access
Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?
Cancer & Metabolism·2014· 70 citedOpen Access
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Frequent Co-authors

Jerry E. Chipuk(21), Jesse D. Gelles(6), Rana Elkholi(5), Shira Wieder(4), Jarvier N. Mohammed(4), Thibaud T. Renault(3), James J. Asciolla(3), Andrew Trotta(3), Jülide Tok Çelebi(3), Kyle L. Hoehn(2), Nadeera M. Wickramasinghe(2), David Sachs(2), Bhavana Shewale(2), David M. Gonzalez(2), Priyanka Dhanan-Krishnan(2), Denis Torre(2), Elizabeth A. LaMarca(2), Serena Raimo(2), Rafael Dariolli(2), Joshua Mayourian(2)