Jesse D. Gelles

Icahn School of Medicine at Mount Sinai — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index486citations30works7.32yr avg
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Research Topics

Cell death mechanisms and regulation(9), Cell Image Analysis Techniques(7), RNA Interference and Gene Delivery(6), Mitochondrial Function and Pathology(5), Advanced Fluorescence Microscopy Techniques(3)

Publications29 total

A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function
Nature Communications·2026Open Access
A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAF <sup>V600E</sup> -Associated Mitochondrial Division in Cancer
2026Open Access
Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival
Cell Communication and Signaling·2025· 4 citedOpen Access
A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function
2024Open Access
Metabolic Adaptations To Acute Glucose Uptake Inhibition Converge Upon Mitochondrial Respiration For Leukemia Cell Survival
2024Open Access
Dynamic death decisions: How mitochondrial dynamics shape cellular commitment to apoptosis and ferroptosis
Developmental Cell·2024· 47 citedOpen Access
The death gaze of MEDUSA
Nature Chemical Biology·2024
An optimized protocol for expression and purification of monomeric full-length BAX protein for functional interrogations
Frontiers in Cell and Developmental Biology·2023· 2 citedOpen Access
An optimized high-yield protocol for expression and purification of monomeric full-length BAX protein
2023Open Access
1723-P: Dual-Label Kinetic Assay to Monitor ß-Cell Death and Proliferation
Diabetes·2023
IFN-γ+ cytotoxic CD4+ T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40
Cellular and Molecular Immunology·2022· 32 citedOpen Access
FLAMBE: A kinetic fluorescence polarization assay to study activation of monomeric BAX
STAR Protocols·2022· 5 citedOpen Access
A kinetic fluorescence polarization ligand assay for monitoring BAX early activation
Cell Reports Methods·2022· 7 citedOpen Access
T cell–derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death
JCI Insight·2021· 20 citedOpen Access
Mechanistic connections between mitochondrial biology and regulated cell death
Developmental Cell·2021· 60 citedOpen Access
A Kinetic Fluorescence Polarization Ligand Assay for Monitoring BAX Early-Activation
SSRN Electronic Journal·2021Open Access
High-Throughput Cell Death Assays with Single-Cell and Population-Level Analyses Using Real-Time Kinetic Labeling (SPARKL)
STAR Protocols·2020· 4 citedOpen Access
Cell death through the ages: The ICDS 25th Anniversary Meeting
FEBS Journal·2020Open Access
Why not add some SPARKL to your life (and death)!?
Molecular & Cellular Oncology·2019Open Access
Single-Cell and Population-Level Analyses Using Real-Time Kinetic Labeling Couples Proliferation and Cell Death Mechanisms
Developmental Cell·2019· 26 citedOpen Access
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Frequent Co-authors

Jerry E. Chipuk(28), Jarvier N. Mohammed(15), Yiyang Chen(8), Madhavika N. Serasinghe(6), Andrew Trotta(5), Mark P.A. Luna‐Vargas(4), Jesminara Khatun(4), Adrian T. Ting(4), Tara M. Sebastian(4), Ioana Abraham‐Enachescu(3), LETÍCIA VITÓRIA DA SILVA SANTOS(3), Stella G. Bayiokos(3), Rana Elkholi(2), Camila Rubio‐Patiño(2), Diana Legarda(2), Monika Komza(2), Juan Henao(2), Ahmed Elsaadi(2), Andriana G. Kotini(2), Cara Clementelli(2)