Johannes L. Bos

Oncode Institute — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

99h-index49.0kcitations301works1.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Protein Kinase Regulation and GTPase Signaling(101), Cancer-related Molecular Pathways(34), Cell Adhesion Molecules Research(34), Virus-based gene therapy research(28), PI3K/AKT/mTOR signaling in cancer(28)

Publications301 total

P02.07 Trial in progress: anti-PD1, capecitabine, and oxaliplatin for the first-line treatment of dMMR esophagogastric cancer (AuspiCiOus-dMMR): a proof-of-principle study (AuspiCiOus)
Poster presentations·2024· 1 citedOpen Access
Data from UNC45A Confers Resistance to Histone Deacetylase Inhibitors and Retinoic Acid
2023Open Access
Data from UNC45A Confers Resistance to Histone Deacetylase Inhibitors and Retinoic Acid
2023Open Access
Supplementary Data from UNC45A Confers Resistance to Histone Deacetylase Inhibitors and Retinoic Acid
2023Open Access
Supplementary Data from UNC45A Confers Resistance to Histone Deacetylase Inhibitors and Retinoic Acid
2023Open Access
Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
Cell Reports·2023· 59 citedOpen Access
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
Nature Cell Biology·2021· 132 citedOpen Access
Drug Repurposing Screen on Patient-Derived Organoids Identifies New Therapeutic Drug Combination Against KRAS Mutant Colon Cancer
SSRN Electronic Journal·2021Open Access
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
Nature Medicine·2019· 799 cited
CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition
Oncotarget·2019· 22 citedOpen Access
A Tuba/Cdc42/Par6A complex is required to ensure singularity in apical domain formation during enterocyte polarization
PLoS ONE·2018· 5 citedOpen Access
The Phosphatase PTPL1 Is Required for PTEN-Mediated Regulation of Apical Membrane Size
Molecular and Cellular Biology·2018· 10 citedOpen Access
Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions
Small GTPases·2018· 22 citedOpen Access
p21ras and Receptor Signaling
2017
From Ras to Rap and Back, a Journey of 35 Years
Cold Spring Harbor Perspectives in Medicine·2017· 27 citedOpen Access
A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization
Molecular and Cellular Biology·2017· 13 citedOpen Access
Ras Association-Domain Dimers Bring Proteins Together
Structure·2016· 1 citedOpen Access
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
eLife·2016· 262 citedOpen Access
Author response: Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
2016· 3 citedOpen Access
ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization
The Journal of Cell Biology·2015· 20 citedOpen Access
page 1 of 16Next →

Frequent Co-authors

Johan de Rooij(8), Boudewijn Burgering(8), Fried Zwartkruis(6), Holger Rehmann(5), Frank Schwede(5), Alfred Wittinghofer(4), René H. Medema(4), Hans‐Gottfried Genieser(4), Alex J. van der Eb(3), Geert J.P.L. Kops(3), Alida M.M. de Vries-Smits(3), Sjoerd Rodenhuis(3), Bas Ponsioen(3), Jorrit M. Enserink(3), Anne Elisabeth Christensen(3), Stein Ove Døskeland(3), A J Boot(3), Matty Verlaan–de Vries(3), A.J. van der Eb(3), Bert Vogelstein(2)