Jennifer Legac

San Francisco General Hospital — United States

Medicine · Health Sciences

24h-index2.1kcitations52works2.92yr avg
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Research Topics

Malaria Research and Control(35), Computational Drug Discovery Methods(17), Mosquito-borne diseases and control(13), HIV/AIDS drug development and treatment(8), Research on Leishmaniasis Studies(6)

Publications52 total

Optimization of Prodiginines as Single-Dose Curative Antimalarials
Journal of Medicinal Chemistry·2025
Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019–2024
Nature Communications·2025· 6 citedOpen Access
Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance
Science Advances·2025Open Access
Optimization of Tambjamines Active against Multiple Stages of Malaria Parasites
Journal of Medicinal Chemistry·2025· 3 cited
Development of Next-Generation Antimalarial Acridones with Radical Cure Potential
Journal of Medicinal Chemistry·2025· 4 cited
Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance
2025· 1 citedOpen Access
Changes in susceptibility of <i>Plasmodium falciparum</i> to antimalarial drugs in Uganda over time: 2019-2024
2025· 10 citedOpen Access
The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh <i>Plasmodium falciparum</i> isolates
Antimicrobial Agents and Chemotherapy·2024· 1 citedOpen Access
<i>Ex vivo</i> susceptibilities to ganaplacide and diversity in potential resistance mediators in Ugandan <i>Plasmodium falciparum</i> isolates
Antimicrobial Agents and Chemotherapy·2024· 1 citedOpen Access
Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda
New England Journal of Medicine·2023· 191 citedOpen Access
Seasonal Malaria Chemoprevention Drug Levels and Drug Resistance Markers in Children With or Without Malaria in Burkina Faso: A Case-Control Study
The Journal of Infectious Diseases·2023· 15 citedOpen Access
Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline
Microbiology Spectrum·2023· 8 citedOpen Access
Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda
Nature Communications·2022· 129 citedOpen Access
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors
Antimicrobial Agents and Chemotherapy·2022· 7 citedOpen Access
The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca2+ Homeostasis by Targeting a Unique Ion Channel
Pharmaceutics·2022· 15 citedOpen Access
The Multistage Antimalarial Compound Calxinin Modulates Calcium Homeostasis Targeting a Unique Calcium Channel Involved in Subcellular Calcium Storage in &lt;i&gt;P. falciparum&lt;/i&gt;
SSRN Electronic Journal·2022Open Access
Identification, Characterization and Synthesis of Natural Parasitic Cysteine Protease Inhibitors – More Potent Falcitidin Analogs
2021Open Access
Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan <i>Plasmodium falciparum</i> Isolates
The Journal of Infectious Diseases·2021· 10 citedOpen Access
Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates
Antimicrobial Agents and Chemotherapy·2021· 6 citedOpen Access
Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum
Malaria Journal·2021· 15 citedOpen Access
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Frequent Co-authors

Philip J. Rosenthal(44), Melissa D. Conrad(22), Patrick K. Tumwebaze(21), Roland A. Cooper(21), Samuel L. Nsobya(18), Stephen Orena(17), Oswald Byaruhanga(16), Jiří Gut(16), Thomas Katairo(14), Martin Okitwi(14), Oriana Kreutzfeld(11), Jeffrey A. Bailey(10), Özkan Aydemir(8), Grant Dorsey(7), Maëlle Duffey(7), Victor Asua(6), Moses R. Kamya(6), Stephanie A. Rasmussen(6), Brett R. Bayles(6), Shreeya Garg(5)