Ciaran D. Scallan

Joint BioEnergy Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index4.4kcitations37works33.72yr avg
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Research Topics

Virus-based gene therapy research(16), CAR-T cell therapy research(10), Viral gastroenteritis research and epidemiology(9), Immunotherapy and Immune Responses(8), Infant Nutrition and Health(7)

Publications37 total

Self-amplifying mRNA expressing COBRA hemagglutinin elicits long-lasting, broadly reactive antibodies against seasonal influenza A viruses
Vaccine·2025Open Access
Differential shaping of T cell responses elicited by heterologous ChAd68/self-amplifying mRNA SIV vaccine in macaques in combination with αCTLA4, αPD-1, or FLT3R agonist
The Journal of Immunology·2025· 1 citedOpen Access
A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results
Nature Medicine·2024· 100 cited
GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults
Nature Communications·2023· 37 citedOpen Access
Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results
Nature Medicine·2022· 206 citedOpen Access
Abstract 3578: Optimization of shared neoantigen vaccine design to increase vaccine potency: From bench to bedside and back
Cancer Research·2022· 1 cited
Abstract 4159: Lower doses of self-amplifying mRNA drive superior neoantigen-specific CD8 T cell responses in cancer patients versus high doses
Cancer Research·2022· 1 cited
Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection
Nature Communications·2022· 53 citedOpen Access
A self-amplifying mRNA COVID-19 vaccine drives potent and broad immune responses at low doses that protects non-human primates against SARS-CoV-2
2021· 5 cited
Abstract 724: A novel heterologous prime boost vaccine system drives tumor specific and potent CD8 T cell responses for cancer immunotherapy
Cancer Research·2018
Orally administered adenoviral-based vaccine induces respiratory mucosal memory and protection against RSV infection in cotton rats
Vaccine·2018· 24 cited
Oral Modeling of an Adenovirus-Based Quadrivalent Influenza Vaccine in Ferrets and Mice
Infectious Diseases and Therapy·2016· 11 citedOpen Access
Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-γ T cell responses in humans
Vaccine·2013· 67 cited
An Adenovirus-Based Vaccine with a Double-Stranded RNA Adjuvant Protects Mice and Ferrets against H5N1 Avian Influenza in Oral Delivery Models
Clinical and Vaccine Immunology·2012· 64 citedOpen Access
Oral Vaccination: Attenuated and Gene-Based
2012
Oral adenoviral-based vaccines: historical perspective and future opportunity
Expert Review of Vaccines·2008· 43 cited
Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy
Blood·2006· 316 citedOpen Access
Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs
Blood·2006· 197 citedOpen Access
Improved coagulation in bleeding disorders by Non-Anticoagulant Sulfated Polysaccharides (NASP)
Thrombosis and Haemostasis·2005· 65 cited
Novel Caprine Adeno-Associated Virus (AAV) Capsid (AAV-Go.1) Is Closely Related to the Primate AAV-5 and Has Unique Tropism and Neutralization Properties
Journal of Virology·2005· 71 citedOpen Access
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Frequent Co-authors

Linda B. Couto(10), Amy Rappaport(10), Karin Jooss(10), Jerry A. Peterson(9), Tongyao Liu(8), Susannah Patarroyo‐White(7), Leonid Gitlin(7), Katherine A. High(6), Haiyan Jiang(6), Glenn F. Pierce(6), Sean N. Tucker(6), Michael R. Taylor(5), Dea Nagy(5), Shangzhen Zhou(5), Christine D. Palmer(5), Meghan G. Hart(5), Jason R. Jaroslavsky(5), Annie Shen(5), Gregory R. Boucher(5), Melissa A. Kachura(5)