Shangzhen Zhou

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

42h-index6.8kcitations86works0.02yr avg
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Research Topics

Virus-based gene therapy research(69), CAR-T cell therapy research(25), CRISPR and Genetic Engineering(22), RNA Interference and Gene Delivery(15), Hemophilia Treatment and Research(15)

Publications86 total

T Cell Predominant Response to AAV-Spike Protects hACE2 Mice from SARS-CoV-2 Pneumonia
2021
Efficacy and Safety of Long-term Prophylaxis in Severe Hemophilia A Dogs Following Liver Gene Therapy Using AAV Vectors
UNC Libraries·2021Open Access
Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs
UNC Libraries·2020Open Access
Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models
Nature Medicine·2019· 86 citedOpen Access
Safety of Same-Eye Subretinal Sequential Readministration of AAV2-hRPE65v2 in Non-human Primates
Molecular Therapy — Methods & Clinical Development·2019· 25 citedOpen Access
AKT3 Gene Transfer Promotes Anabolic Reprogramming and Photoreceptor Neuroprotection in a Pre-clinical Model of Retinitis Pigmentosa
Molecular Therapy·2019· 12 citedOpen Access
CRISPR Activation Enhances In Vitro Potency of AAV Vectors Driven by Tissue-Specific Promoters
Molecular Therapy — Methods & Clinical Development·2019· 18 citedOpen Access
Comparative AAV-eGFP Transgene Expression Using Vector Serotypes 1–9, 7m8, and 8b in Human Pluripotent Stem Cells, RPEs, and Human and Rat Cortical Neurons
Stem Cells International·2019· 37 citedOpen Access
Amelioration of Neurosensory Structure and Function in Animal and Cellular Models of a Congenital Blindness
Molecular Therapy·2018· 26 citedOpen Access
Intravitreal injection of AAV7m8.hLCA5 restores photoreceptor function in Lca5-/- mice to nearly WT levels.
Investigative Ophthalmology & Visual Science·2017Open Access
Successful Phenotype Improvement following Gene Therapy for Severe Hemophilia A in Privately Owned Dogs
PLoS ONE·2016· 28 citedOpen Access
Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII
Blood·2015· 24 citedOpen Access
In Vivo Genome Editing in Neonatal Mouse Liver Preferentially Utilizes Homology Directed Repair
Blood·2015· 1 cited
In vivo genome editing of the albumin locus as a platform for protein replacement therapy
Blood·2015· 295 citedOpen Access
Correction: AAV-Mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models
PLoS ONE·2015· 2 citedOpen Access
Assessing the tropism of adeno-associated virus serotypes in the primate retina for gene therapy
2015
AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice
Blood·2015· 151 citedOpen Access
Unexpected Role of PACE/Furin Cleavage Site in FVIII Biology: Implications for Hemophilia a Therapy
Blood·2014· 1 cited
Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery
Molecular Therapy — Methods & Clinical Development·2014· 41 citedOpen Access
ZFN Mediated Targeting Of Albumin “Safe Harbor” Results In Therapeutic Levels Of Human Factor VIII In a Mouse Model Of Hemophilia A
Blood·2013· 2 cited
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Frequent Co-authors

Katherine A. High(21), Federico Mingozzi(11), J. Fraser Wright(10), Valder R. Arruda(9), Glenn F. Pierce(8), Virginia Haurigot(7), Jonathan D. Finn(7), Arun Srivastava(6), Daniel J. Hui(6), Etiena Basner‐Tschakarjan(6), Haiyan Jiang(5), Linda B. Couto(5), Timothy C. Nichols(5), Samuel L. Murphy(4), Keyun Qing(4), Varavani Dwarki(4), Susannah Patarroyo‐White(4), Tongyao Liu(4), Ciaran D. Scallan(4), Jean Bennett(4)