Lisa Wissler

AstraZeneca (Brazil) — Brazil

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index918citations37works0.02yr avg
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Research Topics

Estrogen and related hormone effects(13), Inflammatory mediators and NSAID effects(5), Genomics, phytochemicals, and oxidative stress(5), Steroid Chemistry and Biochemistry(4), Cytokine Signaling Pathways and Interactions(3)

Publications37 total

The Rise and Fall of SARM1 Base-Exchange Inhibitors
2025
Author response for "A cell-active peptide targeting the Nrf2/Keap1 protein-protein interaction"
2023
Author response for "A cell-active peptide targeting the Nrf2/Keap1 protein-protein interaction"
2023
Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication
Nature Structural & Molecular Biology·2023· 29 citedOpen Access
Correction to “Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein–Protein Interaction”
Journal of Medicinal Chemistry·2023Open Access
Correction to “Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction”
Journal of Medicinal Chemistry·2023Open Access
A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction
Chemical Science·2023· 19 citedOpen Access
Combining structural and coevolution information to unveil allosteric sites
Chemical Science·2023· 16 citedOpen Access
Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein–Protein Interaction
Journal of Medicinal Chemistry·2022· 11 citedOpen Access
CCDC 2190057: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction
Journal of Medicinal Chemistry·2022· 35 citedOpen Access
Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators
Journal of Biological Chemistry·2021· 14 citedOpen Access
Mining Natural Products for Macrocycles to Drug Difficult Targets
Journal of Medicinal Chemistry·2020· 45 citedOpen Access
Molecular tuning of farnesoid X receptor partial agonism
Nature Communications·2019· 94 citedOpen Access
Next generation glucocorticoid receptor modulators
Endocrine Abstracts·2018
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile
Journal of Medicinal Chemistry·2018· 73 citedOpen Access
X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors
Journal of Medicinal Chemistry·2017· 29 citedOpen Access
Glucocorticoid Receptor in complex with compound 4
2017
Glucocorticoid Receptor in complex with AZD9567
2017
Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases
Journal of Medicinal Chemistry·2017· 54 citedOpen Access
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Frequent Co-authors

K. A. P. Edman(18), Matti Lepistö(10), Helena Käck(7), Anders Gunnarsson(7), Stefan Geschwindner(7), T. Hansson(6), Matthew W. D. Perry(6), Ramon Hendrickx(5), Frank Narjes(5), Anna Aagaard(4), Matthew Dearman(4), Markus Berger(4), Martin Hemmerling(4), Hartmut Rehwinkel(4), Jan Dahmén(4), Giuseppina La Sala(4), Claire C. Munier(4), Christian Ottmann(4), Christian Köhler(3), Tina Jellesmark Jensen(3)