T. Hansson

AstraZeneca (Sweden) — Sweden

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index1.2kcitations51works1.02yr avg
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Research Topics

Estrogen and related hormone effects(7), Psoriasis: Treatment and Pathogenesis(6), Neuroendocrine regulation and behavior(5), Pharmacogenetics and Drug Metabolism(4), Aquaculture Nutrition and Growth(4)

Publications51 total

RORγt inverse agonists demonstrating a margin between inhibition of IL-17A and thymocyte apoptosis
PLoS ONE·2025· 1 citedOpen Access
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as <i>Pf</i>eEF2
ChemMedChem·2022· 9 citedOpen Access
AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2
Journal of Medicinal Chemistry·2021· 24 citedOpen Access
Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2
ACS Medicinal Chemistry Letters·2019· 18 cited
Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design
Journal of Medicinal Chemistry·2018· 37 citedOpen Access
Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases
Journal of Medicinal Chemistry·2017· 54 citedOpen Access
The Discovery of Potent and Selective Nonsteroidal Glucocorticoid Receptor Modulators AZD5423 and AZD7594, for the Inhaled Treatment of Respiratory Diseases
Elsevier eBooks·2017
Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators
Bioorganic & Medicinal Chemistry Letters·2016· 17 citedOpen Access
Structure guided design and discovery of Indazole ethers as highly potent, non-steroidal Glucocorticoid receptor modulators
2016
Back Cover: Benzoxazepines Achieve Potent Suppression of IL‐17 Release in Human T‐Helper 17 (T<sub>H</sub>17) Cells through an Induced‐Fit Binding Mode to the Nuclear Receptor RORγ (ChemMedChem 2/2016)
ChemMedChem·2016Open Access
Benzoxazepines Achieve Potent Suppression of IL‐17 Release in Human T‐Helper 17 (T<sub>H</sub>17) Cells through an Induced‐Fit Binding Mode to the Nuclear Receptor RORγ
ChemMedChem·2015· 61 cited
Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)
Bioorganic & Medicinal Chemistry Letters·2015· 15 citedOpen Access
Complex of human hematopoietic prostagandin D2 synthase (hH-PGDS) in complex with an active site inhibitor.
2015
The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation
Bioorganic & Medicinal Chemistry Letters·2014· 33 citedOpen Access
Dissociated non-steroidal glucocorticoid receptor modulators: an update on new compounds
Expert Opinion on Therapeutic Patents·2008· 39 cited
Energetics of nucleophile activation in a protein tyrosine phosphatase
Journal of Molecular Biology·1997· 81 cited
ChemInform Abstract: Synthesis of 2‐(Trimethylsilyl)ethyl 4‐C‐methyl‐β‐D‐ glucopyranuronamide. A Derivative Suitable as Building Block in Synthesis of Phosphoglycolipid Antibiotics.
ChemInform·1996
Synthesis of 2-(Trimethylsilyl)ethyl 4-C-methyl-β-d-gluco-pyranuronamide. a derivative suitable as building block in synthesis of phosphoglycolipid antibiotics
Tetrahedron·1995· 3 cited
Chemotaxonomic evidence for a division of Lactarius vellereus and L. bertillonii as different species
Phytochemistry·1995· 10 cited
The Conversion of [12-2H3]-Labelled Velutinal in Injured Fruit Bodies of Lactarius vellereus. Further Insight into the Biosynthesis of the Russulaceae Sesquiterpenes.
Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry·1993· 12 citedOpen Access
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Frequent Co-authors

Matti Lepistö(9), Kjell Fuxé(7), Frank Narjes(7), Gabriel von Euler(6), Jan-Ακε Gustafsson(6), Lisa Wissler(6), P. Eneroth(6), L.F. Agnati(5), Stefan von Berg(5), Jane McPheat(5), Eva Hansson(5), Johan Jirholt(5), K. A. P. Edman(5), Olov Sterner(5), Roine I. Olsson(4), Yafeng Xue(4), Anna Aagaard(4), Hanna Grindebacke(4), Rongfeng Chen(4), Yao Xiong(4)