Stefan von Berg

AstraZeneca (Sweden) — Sweden

Medicine · Health Sciences

21h-index2.2kcitations33works1.02yr avg
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Research Topics

Alzheimer's disease research and treatments(13), Computational Drug Discovery Methods(9), Cholinesterase and Neurodegenerative Diseases(8), Psoriasis: Treatment and Pathogenesis(6), Asymmetric Synthesis and Catalysis(5)

Publications30 total

RORγt inverse agonists demonstrating a margin between inhibition of IL-17A and thymocyte apoptosis
PLoS ONE·2025· 1 citedOpen Access
AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2
Journal of Medicinal Chemistry·2021· 24 citedOpen Access
Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2
ACS Medicinal Chemistry Letters·2019· 18 cited
A Phenotypic Screening Approach Using Human Treg Cells Identified Regulators of Forkhead Box p3 Expression
ACS Chemical Biology·2019· 16 cited
Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design
Journal of Medicinal Chemistry·2018· 37 citedOpen Access
Back Cover: Benzoxazepines Achieve Potent Suppression of IL‐17 Release in Human T‐Helper 17 (T<sub>H</sub>17) Cells through an Induced‐Fit Binding Mode to the Nuclear Receptor RORγ (ChemMedChem 2/2016)
ChemMedChem·2016Open Access
Benzoxazepines Achieve Potent Suppression of IL‐17 Release in Human T‐Helper 17 (T<sub>H</sub>17) Cells through an Induced‐Fit Binding Mode to the Nuclear Receptor RORγ
ChemMedChem·2015· 61 cited
Combining an amyloid‐beta (Aβ) cleaving enzyme inhibitor with a γ‐secretase modulator results in an additive reduction of Aβ production
FEBS Journal·2014· 21 cited
Revisiting the peripheral sink hypothesis: inhibiting <scp>BACE</scp>1 activity in the periphery does not alter β‐amyloid levels in the <scp>CNS</scp>
Journal of Neurochemistry·2014· 44 cited
Population PKPD Modeling of BACE1 Inhibitor-Induced Reduction in Aβ Levels In Vivo and Correlation to In Vitro Potency in Primary Cortical Neurons from Mouse and Guinea Pig
Pharmaceutical Research·2013· 11 cited
Biotransformation of Two β-Secretase Inhibitors Including Ring Opening and Contraction of a Pyrimidine Ring
Drug Metabolism and Disposition·2013· 5 cited
<scp>AZD</scp>1080, a novel <scp>GSK</scp>3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans
Journal of Neurochemistry·2013· 116 citedOpen Access
Correction to New Aminoimidazoles as β-Secretase (BACE-1) Inhibitors Showing Amyloid-β (Aβ) Lowering in Brain
Journal of Medicinal Chemistry·2012· 1 cited
Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease
Journal of Biological Chemistry·2012· 134 citedOpen Access
New Aminoimidazoles as β-Secretase (BACE-1) Inhibitors Showing Amyloid-β (Aβ) Lowering in Brain
Journal of Medicinal Chemistry·2012· 65 citedOpen Access
Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides
Journal of Medicinal Chemistry·2012· 98 citedOpen Access
Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3β (GSK3β) Inhibitors for Alzheimer’s Disease: Design, Synthesis, and Characterization of Pyrazines
Journal of Medicinal Chemistry·2012· 145 citedOpen Access
Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy
Bioorganic & Medicinal Chemistry Letters·2012· 48 citedOpen Access
Evidence for dimeric BACE-mediated APP processing
Biochemical and Biophysical Research Communications·2010· 23 cited
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
Journal of Clinical Investigation·2009· 269 citedOpen Access
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Frequent Co-authors

Johanna Fälting(11), Yafeng Xue(7), Susanna Eketjäll(7), Karin Kolmodin(6), Britt‐Marie Swahn(6), Jane McPheat(6), Eva Hansson(6), Johan Jirholt(6), T. Hansson(6), Frank Narjes(6), Ratan V. Bhat(5), Fredrik Jeppsson(5), Juliette Janson(5), Sofia Karlström(5), Lise‐Lotte Olsson(5), Biljana Georgievska(5), Roine I. Olsson(5), Anna Aagaard(5), Hanna Grindebacke(5), Rongfeng Chen(5)