Emiliano Peña‐Altamira

King's College London — United Kingdom

Medicine · Health Sciences

19h-index10.0kcitations30works0.02yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(10), Neuroinflammation and Neurodegeneration Mechanisms(8), Alzheimer's disease research and treatments(6), Nerve injury and regeneration(5), Cholinesterase and Neurodegenerative Diseases(5)

Publications30 total

MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in amyotrophic lateral sclerosis-frontotemporal dementia
Brain Communications·2021· 22 citedOpen Access
Dietary Protein Source Influences Brain Inflammation and Memory in a Male Senescence-Accelerated Mouse Model of Dementia
Molecular Neurobiology·2020· 4 citedOpen Access
MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in ALS-FTD
2020Open Access
Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss
Acta Neuropathologica Communications·2019· 87 citedOpen Access
Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo
International Journal of Molecular Sciences·2019· 22 citedOpen Access
Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment, activation and neurotoxicity and is counteracted by the autophagy inducer trehalose
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2018· 44 cited
A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential
ACS Chemical Neuroscience·2018· 20 cited
Release of soluble and vesicular purine nucleoside phosphorylase from rat astrocytes and microglia induced by pro-inflammatory stimulation with extracellular ATP via P2X 7 receptors
Neurochemistry International·2017· 25 cited
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents
European Journal of Medicinal Chemistry·2017· 73 citedOpen Access
Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer’s Disease
Frontiers in Aging Neuroscience·2017· 44 citedOpen Access
Evidence for purine nucleoside phosphorylase (PNP) release from rat C6 glioma cells
Journal of Neurochemistry·2017· 13 citedOpen Access
Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2017· 32 citedOpen Access
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
European Journal of Medicinal Chemistry·2016· 107 citedOpen Access
Down-regulation of mitochondrial aspartate/glutamate carrier isoform 1 in Neuro2A cells inhibits cell proliferation and N-acetyl-aspartate synthesis.
Biochimica et Biophysica Acta (BBA) - Bioenergetics·2016
Zinc supplementation in rats impairs hippocampal-dependent memory consolidation and dampens post-traumatic recollection of stressful event
European Neuropsychopharmacology·2016· 12 cited
Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation
Expert Opinion on Therapeutic Targets·2015· 70 cited
Neuronal Regulation of Neuroprotective Microglial Apolipoprotein E Secretion in Rat In Vitro Models of Brain Pathophysiology
Journal of Neuropathology & Experimental Neurology·2015· 15 cited
Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects
Journal of Medicinal Chemistry·2014· 148 citedOpen Access
The transcription factor <scp>CCAAT</scp> enhancer‐binding protein β protects rat cerebellar granule neurons from apoptosis through its transcription‐activating isoforms
European Journal of Neuroscience·2013· 20 cited
Histone Post-translational Modifications in Huntington&amp;#8217;s and Parkinson&amp;#8217;s Diseases
Current Pharmaceutical Design·2013· 18 cited
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Frequent Co-authors

Barbara Monti(21), Marco Virgili(14), Antonio Contestabile(10), Elisabetta Polazzi(9), Sabrina Petralla(9), Francesca Massenzio(9), María Laura Bolognesi(6), Ilaria Mengoni(5), Elisa Uliassi(3), Manuela Bartolini(3), Marinella Roberti(3), Matthew A. White(3), Eugene Kim(3), Christopher M. Henstridge(3), Isobel Callaghan(3), Camilla Simmons(3), Diana Cash(3), Michael P. Coleman(3), Jemeen Sreedharan(3), Emanuela Profilo(3)