Franklin Schlerman

Pfizer (United States) — United States

Medicine · Health Sciences

12h-index922citations24works93.52yr avg
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Research Topics

Liver Disease Diagnosis and Treatment(6), Asthma and respiratory diseases(4), IL-33, ST2, and ILC Pathways(4), Chronic Obstructive Pulmonary Disease (COPD) Research(3), Chronic Kidney Disease and Diabetes(3)

Publications24 total

Myeloid cells contribute to bystander CD8 T cell accumulation in metabolic-associated steatohepatitis and are sufficient for fibrosis
2025Open Access
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)
Nature Metabolism·2024· 187 citedOpen Access
A protein kinase C α and β inhibitor blunts hyperphagia to halt renal function decline and reduces adiposity in a rat model of obesity-driven type 2 diabetes
Scientific Reports·2023· 1 citedOpen Access
Molecular MR Imaging of Renal Fibrogenesis in Mice
Journal of the American Society of Nephrology·2023· 18 citedOpen Access
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation
Science Immunology·2023· 245 cited
Is there a murine model that fully recapitulates human NASH? An unbiased bioinformatics approach to rank pre-clinical models based on proximity to human disease
Journal of Hepatology·2022· 1 cited
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1
Journal of Medicinal Chemistry·2021· 19 citedOpen Access
Author Correction: Quantitative, noninvasive MRI characterization of disease progression in a mouse model of non-alcoholic steatohepatitis
Scientific Reports·2021· 2 citedOpen Access
Quantitative, noninvasive MRI characterization of disease progression in a mouse model of non-alcoholic steatohepatitis
Scientific Reports·2021· 12 citedOpen Access
Pharmacologic inhibition of Protein Kinase C α and Protein Kinase C β halts renal function decline indirectly, by blunting hyperphagia, and directly reduces adiposity in the ZSF1 rat model of type 2 diabetes
2020Open Access
Advanced MRI of Liver Fibrosis and Treatment Response in a Rat Model of Nonalcoholic Steatohepatitis
Radiology·2020· 40 citedOpen Access
Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH)
PLoS ONE·2019· 60 citedOpen Access
Combined inhibition of CCR2 and ACE provides added protection against progression of diabetic nephropathy in <i>Nos3</i>-deficient mice
American Journal of Physiology-Renal Physiology·2019· 12 citedOpen Access
High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy
PLoS ONE·2017· 23 citedOpen Access
Histomorphometry of intra-acinar vessel muscularization in the rat sugen/hypoxia efficacy model of pulmonary arterial hypertension
Journal of Pharmacological and Toxicological Methods·2017· 1 cited
Characterization of MMP-9 and -12 KO mice in a model of acute smoke exposure
Journal of Inflammation·2013Open Access
Development of a model of Ascaris Suum antigen-induced pulmonary inflammation in nonhuman primates
Journal of Inflammation·2013· 1 citedOpen Access
A COPD-like model of viral exacerbation: synergistic effects with smoke and poly I:C
Journal of Inflammation·2013Open Access
Lipopolysaccharide (LPS) segmental lung challenge in nonhuman primates – a model of airway inflammation
Journal of Inflammation·2013Open Access
A Selective Matrix Metalloprotease 12 Inhibitor for Potential Treatment of Chronic Obstructive Pulmonary Disease (COPD): Discovery of (<i>S</i>)-2-(8-(Methoxycarbonylamino)dibenzo[<i>b</i>,<i>d</i>]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408)
Journal of Medicinal Chemistry·2009· 102 citedOpen Access
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Frequent Co-authors

Samuel J. Goldman(7), Robert V. Martinez(7), Joseph P. Sypek(6), Andrea G. Bree(6), Matthew P. Lech(4), Ken Dower(4), Cara Williams(4), Michael Wadanoli(4), Yutian Zhan(4), Baohong Zhang(4), Nicholas J. Rotile(4), Jeremy Wellen(4), Bryan C. Fuchs(4), Peter Caravan(4), James B. McMahon(3), Michèle Vacca(3), Ioannis Kamzolas(3), Fiona Oakley(3), Ann K. Daly(3), Valérie Paradis(3)