Joseph P. Sypek

Takeda (United States) — United States

Medicine · Health Sciences

31h-index3.7kcitations67works0.02yr avg
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Research Topics

Research on Leishmaniasis Studies(25), Asthma and respiratory diseases(11), Immune Cell Function and Interaction(8), Macrophage Migration Inhibitory Factor(8), Parasites and Host Interactions(6)

Publications67 total

Gene therapy for cross-correction of somatic organs and the CNS in mucopolysaccharidosis II in rodents and non-human primates
Molecular Therapy — Methods & Clinical Development·2023· 10 citedOpen Access
Targeted Therapy of Acute Chest Syndrome with Recombinant Heme Oxygenase-1 Revealed By the Resistance of Young Transgenic Sickle Cell Mice to Heme-Induced Acute Lung Injury
Blood·2019· 1 cited
490c – C1Inh: A Novel Therapeutic Target to Treat Biliary Atresia and Liver Fibrosis
Gastroenterology·2019
Characterization of MMP-9 and -12 KO mice in a model of acute smoke exposure
Journal of Inflammation·2013Open Access
Development of a model of Ascaris Suum antigen-induced pulmonary inflammation in nonhuman primates
Journal of Inflammation·2013· 1 citedOpen Access
Lipopolysaccharide (LPS) segmental lung challenge in nonhuman primates – a model of airway inflammation
Journal of Inflammation·2013Open Access
Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD)
Bioorganic & Medicinal Chemistry Letters·2011· 34 citedOpen Access
Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults
Journal of Allergy and Clinical Immunology·2010· 68 cited
Identification of an Orally Efficacious Matrix Metalloprotease 12 Inhibitor for Potential Treatment of Asthma
Journal of Medicinal Chemistry·2009· 38 citedOpen Access
A Selective Matrix Metalloprotease 12 Inhibitor for Potential Treatment of Chronic Obstructive Pulmonary Disease (COPD): Discovery of (<i>S</i>)-2-(8-(Methoxycarbonylamino)dibenzo[<i>b</i>,<i>d</i>]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408)
Journal of Medicinal Chemistry·2009· 102 citedOpen Access
Correction: Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis
Arthritis Research & Therapy·2009Open Access
Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis
Arthritis Research & Therapy·2008· 48 citedOpen Access
Abstract 3718: MMP-12 Inhibitor Reduces Severity of ANGII-induced Aortic Abdominal Aneurysms in apoE−/− Mice
Circulation·2008· 2 cited
Human Alveolar Macrophage Gene Responses to <i>Mycobacterium tuberculosis</i> Strains H37Ra and H37Rv
American Journal of Respiratory Cell and Molecular Biology·2008· 64 citedOpen Access
Interleukin-13 Neutralization by Two Distinct Receptor Blocking Mechanisms Reduces Immunoglobulin E Responses and Lung Inflammation in Cynomolgus Monkeys
Journal of Pharmacology and Experimental Therapeutics·2008· 45 cited
IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys
Journal of Allergy and Clinical Immunology·2007· 71 cited
Gob-5 Contributes to Goblet Cell Hyperplasia and Modulates Pulmonary Tissue Inflammation
American Journal of Respiratory Cell and Molecular Biology·2006· 66 cited
Gene expression analysis in a murine model of allergic asthma reveals overlapping disease and therapy dependent pathways in the lung
The Pharmacogenomics Journal·2006· 26 cited
Antagonizing Deactivating Cytokines To Enhance Host Defense and Chemotherapy in Experimental Visceral Leishmaniasis
Infection and Immunity·2005· 73 citedOpen Access
Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray
Journal of Allergy and Clinical Immunology·2004· 120 cited
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Frequent Co-authors

Samuel J. Goldman(11), David J. Wyler(10), Charles L. Chung(7), Lisa Schopf(6), Cara Williams(5), Debra D. Donaldson(4), Xin Xu(4), Steve Tam(4), Nancy Wood(3), Bruce A. Jacobson(3), Marion T. Kasaian(3), Jianchang Li(3), Yuchuan Wu(3), Rajeev Hotchandani(3), Kristina Cunningham(3), Franklin Schlerman(3), Tarek S. Mansour(3), Rustem Krykbaev(3), Susan Fish(3), Liz M. Lavigne(3)