Rustem Krykbaev

Massachusetts General Hospital — United States

Medicine · Health Sciences

10h-index475citations17works0.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(4), Studies on Chitinases and Chitosanases(4), Invertebrate Immune Response Mechanisms(3), Toxin Mechanisms and Immunotoxins(3), Asthma and respiratory diseases(2)

Publications17 total

DEPCOD: a tool to detect and visualize co-evolution of protein domains
Nucleic Acids Research·2022· 3 citedOpen Access
Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD)
Bioorganic & Medicinal Chemistry Letters·2011· 34 citedOpen Access
Implications For Acidic Mammalian Chitinase In Mouse Allergic Airway Disease
2010
Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice
Arthritis & Rheumatism·2010· 74 cited
Evolutionary and biochemical differences between human and monkey acidic mammalian chitinases
Gene·2009· 32 cited
A fluorescent assay suitable for inhibitor screening and vanin tissue quantification
Analytical Biochemistry·2009· 47 cited
The novel and selective JAK3 inhibitor WYE-152038 is highly efficacious in a mouse model of rheumatoid arthritis
Cytokine·2009
Identification of an Orally Efficacious Matrix Metalloprotease 12 Inhibitor for Potential Treatment of Asthma
Journal of Medicinal Chemistry·2009· 38 citedOpen Access
Triad of polar residues implicated in pH specificity of acidic mammalian chitinase
Protein Science·2009· 69 citedOpen Access
IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys
Journal of Allergy and Clinical Immunology·2007· 71 cited
Kinetic Characterization of Recombinant Human Acidic Mammalian Chitinase
Biochemistry·2006· 67 cited
Modifying specificity of antidigoxin antibodies using insertional mutagenesis
Protein Science·2002· 10 citedOpen Access
Complementary Combining Site Contact Residue Mutations of the Anti-digoxin Fab 26–10 Permit High Affinity Wild-type Binding
Journal of Biological Chemistry·2002· 12 citedOpen Access
Phage Display-selected Sequences of the Heavy-chain CDR3 Loop of the Anti-digoxin Antibody 26-10 Define a High Affinity Binding Site for Position 16-substituted Analogs of Digoxin
Journal of Biological Chemistry·2001· 9 citedOpen Access
Mutant CD4 Molecules with Improved Binding to HIV Envelope Protein gp120 Selected by Phage Display
Virology·1997· 7 cited
[Expression of orthopoxvirus DNA sequences in Escherichia coli cells].
PubMed·1992
trp operon induction during the expression in <i>E. coli</i> of two IFN‐γ sequences
FEBS Letters·1987· 2 citedOpen Access

Frequent Co-authors

Lori Fitz(5), Steve Tam(4), Dejun Xuan(4), Margaret Fleming(4), Tarek S. Mansour(3), Xin Xu(3), Samuel J. Goldman(3), Joseph P. Sypek(3), Cara Williams(3), Philip D. Jeffrey(3), Michael N. Margolies(3), Tsung H. Lin(2), Martin Hegen(2), Elizabeth Quadros(2), Cheryl Nickerson‐Nutter(2), Kenneth C. Appell(2), Andrew G. Cole(2), Yuefei Shao(2), Michael Ohlmeyer(2), Bojing Wang(2)