Kurt Deshayes

Biochemistry, Genetics and Molecular Biology · Life Sciences

38h-index7.9kcitations84works0.02yr avg
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Research Topics

Cell death mechanisms and regulation(23), Monoclonal and Polyclonal Antibodies Research(12), Ubiquitin and proteasome pathways(12), NF-κB Signaling Pathways(9), Glycosylation and Glycoproteins Research(8)

Publications84 total

A Non-immunogenic Bivalent <scp>d</scp>-Protein Potently Inhibits Retinal Vascularization and Tumor Growth
ACS Chemical Biology·2021· 31 cited
D-Protein RFX-V2 Bound to the VEGFR1 Domain 3 Site on VEGF-A
2021
D-Protein RFX-V1 Bound to the VEGFR1 Domain 2 Site on VEGF-A
2021
The SARS-CoV-2 Spike Protein D614G Mutation Shows Increasing Dominance and May Confer a Structural Advantage to the Furin Cleavage Domain
Preprints.org·2020· 20 citedOpen Access
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
Molecular Cell·2018· 116 citedOpen Access
Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers
Oncotarget·2016· 14 citedOpen Access
Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies
Journal of Molecular Biology·2016· 11 citedOpen Access
Development of Orthogonally Protected Hypusine for Solid-Phase Peptide Synthesis
The Journal of Organic Chemistry·2015· 3 cited
By Any Means Necessary: Discovering a Bcl-xL Specific Domain
Journal of Molecular Biology·2014
Discovery of a Potent and Selective BCL-X <sub>L</sub> Inhibitor with <i>in Vivo</i> Activity
ACS Medicinal Chemistry Letters·2014· 328 citedOpen Access
Further Insights into the Effects of Pre-organizing the BimBH3 Helix
ACS Chemical Biology·2014· 27 cited
Structure-guided design of a selective BCL-XL inhibitor
Nature Chemical Biology·2013· 370 citedOpen Access
OTUB1 modulates c‐IAP1 stability to regulate signalling pathways
The EMBO Journal·2013· 117 citedOpen Access
Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity
ACS Chemical Biology·2012· 134 cited
Characterization of ML-IAP protein stability and physiological role <i>in vivo</i>
Biochemical Journal·2012· 18 cited
Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner
Oncogene·2012· 87 cited
Abstract 2151: Activation of NF-kB and MAP kinases by TNF Family Receptors is regulated by cellular IAPs
Cancer Research·2012
Cellular Inhibitors of Apoptosis Are Global Regulators of NF-κB and MAPK Activation by Members of the TNF Family of Receptors
Science Signaling·2012· 190 cited
Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)
Journal of Medicinal Chemistry·2012· 247 citedOpen Access
The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer
Topics in medicinal chemistry·2012· 4 cited
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Frequent Co-authors

Kerry Zobel(21), Domagoj Vucic(19), Wayne J. Fairbrother(17), Anna Fedorova(14), Eugene Varfolomeev(9), John A. Flygare(7), Linda O. Elliott(6), Tatiana Goncharov(6), Piotr Piotrowiak(6), Jasmin N. Dynek(5), Heidi J.A. Wallweber(5), Vishva M. Dixit(5), Peter E. Czabotar(5), Brian J. Smith(5), Anita Izrael-Tomasevic(5), Donald S. Kirkpatrick(5), Sachdev S. Sidhu(5), M. Ángeles Farrán(5), Peter M. Colman(4), David C.S. Huang(4)