Christian Ducho

Pharmaceutical Biotechnology (Czechia) — Czech Republic

Medicine · Health Sciences

26h-index1.9kcitations114works1.02yr avg
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Research Topics

Microbial Natural Products and Biosynthesis(28), Carbohydrate Chemistry and Synthesis(19), Chemical Synthesis and Analysis(18), Advanced biosensing and bioanalysis techniques(15), Biochemical and Molecular Research(14)

Publications114 total

1,2,4-Triazole-Based First-in-Class Non-Nucleoside Inhibitors of the Bacterial Enzyme MraY
ACS Bio & Med Chem Au·2025· 1 citedOpen Access
1,2,4-Triazole-based first-in-class non-nucleoside inhibitors of bacterial enzyme MraY
2025Open Access
Getting the Numbers Right in Medicinal Chemistry
ChemMedChem·2024· 2 citedOpen Access
Inhibitors of the Elastase LasB for the Treatment of <i>Pseudomonas aeruginosa</i> Lung Infections
ACS Central Science·2023· 20 citedOpen Access
Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting <i>Mycobacterium tuberculosis</i>
ACS Infectious Diseases·2023· 10 citedOpen Access
Discovery of 1,2-diaryl-3-oxopyrazolidin-4-carboxamides as a new class of MurA enzyme inhibitors and characterization of their antibacterial activity
European Journal of Medicinal Chemistry·2023· 8 citedOpen Access
Targeting the binding pocket of the fluorophore 8‐anilinonaphthalene‐1‐sulfonic acid in the bacterial enzyme MurA
Archiv der Pharmazie·2023· 8 citedOpen Access
Inhibitors of the Elastase LasB for the treatment of Pseudomonas aeruginosa lung infections
2023· 3 citedOpen Access
GreenMedChem: the challenge in the next decade toward eco-friendly compounds and processes in drug design
Green Chemistry·2023· 127 citedOpen Access
Nucleoside-derived inhibitors of MraY: Medicinal chemistry with natural products
Annual reports in medicinal chemistry·2023· 1 cited
Inhibitors of the bacterial enzyme MurA as potential novel antibiotics
Annual reports in medicinal chemistry·2023
Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting <i>Mycobacterium tuberculosis</i>
2022· 1 citedOpen Access
Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA
Journal of Medicinal Chemistry·2022· 5 citedOpen Access
Synthesis of an Antimicrobial Enterobactin‐Muraymycin Conjugate for Improved Activity Against Gram‐Negative Bacteria
Chemistry - A European Journal·2022· 20 citedOpen Access
N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH
2022· 6 citedOpen Access
Inhibition of Collagenase Q1 of <i>Bacillus cereus</i> as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections
Advanced Therapeutics·2022· 13 citedOpen Access
Enzymatic C<sub>β</sub>–H Functionalization of <scp>l</scp>-Arg and <scp>l</scp>-Leu in Nonribosomally Derived Peptidyl Natural Products: A Tale of Two Oxidoreductases
Journal of the American Chemical Society·2021· 10 citedOpen Access
Front Cover: Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH) (ChemMedChem 8/2021)
ChemMedChem·2021Open Access
A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders
European Journal of Medicinal Chemistry·2021· 32 citedOpen Access
Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH)
ChemMedChem·2021· 17 citedOpen Access
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Frequent Co-authors

Anatol P. Spork(10), Stefan Koppermann(10), Steven G. Van Lanen(9), Daniel D. Wiegmann(7), Refaat B. Hamed(6), Christopher J. Schofield(6), Zheng Cui(6), Jon S. Thorson(6), Giuliana Niro(5), Oliver Ries(5), Xiachang Wang(5), Chris Meier(5), Anke Lemke(4), Jörg Haupenthal(4), Katrin Voos(4), Rolf W. Hartmann(4), Jan Balzarini(4), Timothy D. W. Claridge(4), J. Rúben Gómez Castellanos(3), Koichi Nonaka(3)