Christopher J. Schofield

Mansfield University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

112h-index62.1kcitations1.3kworks3.72yr avg
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Research Topics

Cancer, Hypoxia, and Metabolism(278), Epigenetics and DNA Methylation(145), Antibiotic Resistance in Bacteria(121), Metal-Catalyzed Oxygenation Mechanisms(118), Enzyme Structure and Function(80)

Publications1.3k total

Drop on fixed target reaction initiation approach for serial and time resolved crystallography
2025Open Access
Structural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi syndrome
Journal of Biological Chemistry·2025· 1 citedOpen Access
Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease
2025Open Access
Inhibition of systemic mammalian metabolism by carnitine mimics from the gut microbiota
2025Open Access
Small but powerful
Nature Reviews Chemistry·2025
Cellular and functional insights into FIH-mediated hydroxylation of TRPA1
Journal of Biological Chemistry·2025Open Access
Profiling Inhibitor Scaffolds for the Cancer Target Jumonji‐C Domain‐Containing Protein 6
ChemMedChem·2025Open Access
Targeting mycobacterial transpeptidases: evaluating the roles of Ldt and PBP inhibition in suppressing <i>Mycobacterium smegmatis</i>
Antimicrobial Agents and Chemotherapy·2025Open Access
Evidence human FTO catalyses hydroxylation of <i>N</i>6-methyladenosine without direct formation of a demethylated product contrasting with ALKBH5/2/3 and bacterial AlkB
Nucleic Acids Research·2025· 1 citedOpen Access
Revealing the catalytic mechanism of the Fe(II)/2-oxoglutarate-dependent human epigenetic modifying enzyme ALKBH5
Cell Reports Physical Science·2025· 1 citedOpen Access
<i>ob</i> ABPP-HT*: A Precision-Engineered Activity Proteomics Pipeline for the Streamlined Discovery of Deubiquitinase Inhibitors
2025· 2 citedOpen Access
Light-Induced, Lysine-Targeting Irreversible Covalent Inhibition of the Human Oxygen Sensing Hydroxylase Factor Inhibiting HIF (FIH)
Journal of the American Chemical Society·2025· 2 citedOpen Access
Filamin C dimerisation is regulated by HSPB7
Nature Communications·2025· 4 citedOpen Access
Derivatives of the Clinically Used HIF Prolyl Hydroxylase Inhibitor Desidustat Are Efficient Inhibitors of Human γ-Butyrobetaine Hydroxylase
Journal of Medicinal Chemistry·2025· 5 citedOpen Access
Silaproline-bearing nirmatrelvir derivatives are potent inhibitors of the SARS-CoV-2 main protease highlighting the value of silicon-derivatives in structure-activity-relationship studies
European Journal of Medicinal Chemistry·2025· 3 citedOpen Access
Evaluation of 2-( <i>1H</i> -1,2,3-triazol-1-yl) acetic acid derivatives as potential human hypoxia-inducible factor (HIF) prolyl hydroxylase domain-2 (PHD2) inhibitors
Pure and Applied Chemistry·2025Open Access
Targeting Mycobacterial Transpeptidases: Evaluating the Roles of Ldt and PBP Inhibition in Suppressing <i>Mycobacterium smegmatis</i>
2025
Author Correction: Normal tissue radioprotection by amifostine via Warburg-type effects
Scientific Reports·2025Open Access
Dynamic kinetic resolution-mediated synthesis of C-3 hydroxylated arginine derivatives
Royal Society Open Science·2025Open Access
Front Cover: Origins of Catalysis in Non‐Heme Fe(II)/2‐Oxoglutarate‐Dependent Histone Lysine Demethylase KDM4A with Differently Methylated Histone H3 Peptides (Chem. Eur. J. 3/2025)
Chemistry - A European Journal·2025Open Access
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Frequent Co-authors

M.A. McDonough(15), Peter J. Ratcliffe(14), Kirsty S. Hewitson(11), I.J. Clifton(10), Christopher W. Pugh(7), Luke A. McNeill(7), Rasheduzzaman Chowdhury(7), Christoph Loenarz(6), Nathan R. Rose(5), Akane Kawamura(5), Udo Oppermann(5), Neil J. Oldham(5), Ya‐Min Tian(4), Timothy D. W. Claridge(4), Jack E. Baldwin(4), Emily Flashman(4), Benoît M. R. Liénard(4), Jasmin Mecinović(4), David R. Mole(3), Michael Wilson(3)