Christoph Loenarz

University of Freiburg — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index3.9kcitations53works6.02yr avg
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Research Topics

Cancer, Hypoxia, and Metabolism(31), Epigenetics and DNA Methylation(16), RNA modifications and cancer(16), Mitochondrial Function and Pathology(8), Metal-Catalyzed Oxygenation Mechanisms(7)

Publications53 total

Identification and Characterization of Pyrimidine Nucleoside 2′-Hydroxylase
ACS Catalysis·2025· 6 citedOpen Access
β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner
Proceedings of the National Academy of Sciences·2023· 15 citedOpen Access
Non‐canonical nucleosides: Biomimetic triphosphorylation, incorporation into mRNA and effects on translation and structure
FEBS Journal·2023· 11 citedOpen Access
Biomimetic <i>S</i> ‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes**
ChemBioChem·2023· 31 citedOpen Access
β-Lapachone Regulates Mammalian Inositol Pyrophosphate Levels in an NQO1- and Oxygen-dependent Manner
2022· 1 citedOpen Access
Biomimetic S-Adenosylmethionine Regeneration Starting from Different Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes
2022· 1 citedOpen Access
A Cobalamin‐Dependent Radical SAM Enzyme Catalyzes the Unique C<sub>α</sub>‐Methylation of Glutamine in Methyl‐Coenzyme M Reductase
Angewandte Chemie·2022· 3 citedOpen Access
A Cobalamin‐Dependent Radical SAM Enzyme Catalyzes the Unique C <sub>α</sub> ‐Methylation of Glutamine in Methyl‐Coenzyme M Reductase
Angewandte Chemie International Edition·2022· 19 citedOpen Access
Ein Gespür für Sauerstoff: Entdeckung des molekularen Mechanismus der zellulären Sauerstoffregulation rückt die Hydroxylierung von Makromolekülen in den Blickpunkt
Angewandte Chemie·2020
An Oxygen Sensation: Progress in Macromolecule Hydroxylation Triggered by the Elucidation of Cellular Oxygen Sensing
Angewandte Chemie International Edition·2020· 5 cited
Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding
Chemistry - A European Journal·2018· 12 citedOpen Access
Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal &lt;em&gt;Trichoplax adhaerens&lt;/em&gt;
Hypoxia·2018· 24 citedOpen Access
Studies on the Substrate Selectivity of the Hypoxia‐Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain
ChemBioChem·2018· 6 citedOpen Access
YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase
Extremophiles·2018· 6 citedOpen Access
Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens
SHILAP Revista de lepidopterología·2018· 1 citedOpen Access
Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase
Biochemistry·2015· 24 citedOpen Access
Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases
Structure·2015· 39 citedOpen Access
Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2)
Journal of Biological Chemistry·2014· 51 citedOpen Access
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
Proceedings of the National Academy of Sciences·2014· 123 citedOpen Access
Sudestada1, a <i>Drosophila</i> ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
Proceedings of the National Academy of Sciences·2014· 52 citedOpen Access
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Frequent Co-authors

Christopher J. Schofield(35), Rasheduzzaman Chowdhury(11), M.A. McDonough(10), Peter J. Ratcliffe(10), Emily Flashman(9), Wei Ge(8), Armin Thalhammer(8), Jasmin Mecinović(7), Rok Sekirnik(5), Matthew E. Cockman(5), Henning J. Jessen(5), Jennifer N. Andexer(5), Udo Oppermann(4), Mathew L. Coleman(4), Benedikt M. Kessler(4), Lukas Gericke(4), Sören Jahn(4), Jana Gagsteiger(4), Gunhild Layer(4), Hanna Tarhonskaya(4)