Zhong-zuo Yan

Shenyang Pharmaceutical University — China

Medicine · Health Sciences

6h-index124citations9works6.02yr avg
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Research Topics

Antifungal resistance and susceptibility(8), Synthesis and Biological Evaluation(7), Fungal Infections and Studies(2), Phytochemical compounds biological activities(2), Organoboron and organosilicon chemistry(1)

Publications9 total

Discovery of Novel NO–Donor Containing hCA II Inhibitors with Retinal Ganglion Cell-Protective Effects for the Efficient Treatment of Glaucoma
Journal of Medicinal Chemistry·2025
Discovery of Novel α,β-Unsaturated Amide Derivatives as Candidate Antifungals to Overcome Fungal Resistance
Journal of Medicinal Chemistry·2024· 12 cited
Developing Novel Coumarin-Containing Azoles Antifungal Agents by the Scaffold Merging Strategy for Treating Azole-Resistant Candidiasis
Journal of Medicinal Chemistry·2023· 25 cited
Design, synthesis, and biological evaluation of novel boron-containing azoles as potential antifungal agents
Journal of Molecular Structure·2023· 4 cited
Design, synthesis and antifungal activities of novel triazole derivatives with selenium-containing hydrophobic side chains
Bioorganic & Medicinal Chemistry Letters·2022· 13 cited
Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51
European Journal of Medicinal Chemistry·2022· 23 cited
Design, synthesis, and biological evaluation of selenium-containing small molecule compounds based on the dual mechanism of fungal CYP51 inhibition and fungal ROS generation
Journal of Molecular Structure·2022· 6 cited
Discovery of 1,2,3-selenadiazole analogues as antifungal agents using a scaffold hopping approach
Bioorganic Chemistry·2021· 16 cited
Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections
European Journal of Medicinal Chemistry·2021· 25 cited

Frequent Co-authors

Mengbi Guo(9), Zhuang Hou(9), Chun Guo(9), Hang Xu(6), Xin Wang(6), Yanhua Mou(6), Rui Zhang(3), Dongze Zhao(3), Ran An(2), Xin Su(2), Chun Cao(2), Ping Gong(2), Yitong Wang(2), Yanxiu Huang(1), Zengye Li(1), Yu Wei(1), Yitong Wang(1), Ran An(1), En-hui Dong(1), Qi Li(1)