Stephen Benoit

Pfizer (United States) — United States

Medicine · Health Sciences

20h-index2.4kcitations31works0.02yr avg
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Research Topics

Platelet Disorders and Treatments(10), Psoriasis: Treatment and Pathogenesis(7), Blood Coagulation and Thrombosis Mechanisms(5), T-cell and B-cell Immunology(4), Antiplatelet Therapy and Cardiovascular Diseases(4)

Publications31 total

Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning
ACS Medicinal Chemistry Letters·2018· 27 citedOpen Access
Supplementary Material for: Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis
Figshare·2016Open Access
Supplementary Material for: Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis
Figshare·2016Open Access
Modeling the Clinical Phenotype of BTK Inhibition in the Mature Murine Immune System
The Journal of Immunology·2014· 27 citedOpen Access
Selective Inhibition of BTK Prevents Murine Lupus and Antibody-Mediated Glomerulonephritis
The Journal of Immunology·2013· 108 cited
Enhanced <scp>GITR</scp>/<scp>GITRL</scp> interactions augment <scp>IL</scp>‐27 expression and induce <scp>IL</scp>‐10‐producing Tr‐1 like cells
European Journal of Immunology·2012· 46 cited
PS1-06 TNFα blockade exacerbates murine psoriasis-like skin inflammation by enhancing Th17 function and preventing expansion of regulatory T cells
Cytokine·2010
Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality
Journal of Leukocyte Biology·2010· 73 cited
Tumor necrosis factor α blockade exacerbates murine psoriasis‐like disease by enhancing Th17 function and decreasing expansion of Treg cells
Arthritis & Rheumatism·2010· 131 cited
Title: CD8+CD62LhiCD25- cells induce skin inflammation in a psoriasis-like disease model and exhibit a Th1 phenotype (137.19)
The Journal of Immunology·2009
S.101. TNFa Blockade Exacerbates Disease in a Psoriasis-like Skin Inflammation Model Through Enhancing Th17 Cell Function while Suppressing CD4+Foxp3+T Cell Expansion
Clinical Immunology·2009
Glucocorticoid induced TNF Receptor Ligand (GITRL) transgenic mice develop T and B lymphocyte hyperplasia and expansion of CD4+ FOXP3+ cells
The FASEB Journal·2008
IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation
Journal of Clinical Investigation·2008· 538 citedOpen Access
IL-22 is Required for Th17 Cell Mediated Skin Inflammation in Murine Model of Psoriasis
Clinical Immunology·2008
IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis
The Journal of Immunology·2007· 175 citedOpen Access
Cell-surface and cytokine biomarkers in autoimmune and inflammatory diseases
Drug Discovery Today·2006· 15 cited
Sa.140. Neutralization of Interleukin 21 Results in Suppression of Colitis in Mice Adoptively Transplanted with CD45RBHi CD4+ T-Cells
Clinical Immunology·2006
Enoxaparin, a Low Molecular Weight Heparin, Inhibits Platelet-Dependent Prothrombinase Assembly and Activity by Factor-Xa Neutralization
Journal of Thrombosis and Thrombolysis·2000· 23 cited
The Cleaved Peptide of PAR1 Results in a Redistribution of the Platelet Surface GPIb-IX-V Complex to the Surface-Connected Canalicular System
Thrombosis and Haemostasis·2000· 38 cited
Nitric Oxide Inhibits Thrombin Receptor-activating Peptide-induced Phosphoinositide 3-Kinase Activity in Human Platelets
Journal of Biological Chemistry·1999· 101 citedOpen Access
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Frequent Co-authors

Alan D. Michelson(11), Mary Collins(8), Cheryl Nickerson‐Nutter(8), Deborah Young(7), Lee Napierata(6), Nancy Stedman(6), Marc R. Barnard(5), John Douhan(5), Joy Miyashiro(4), Kyri Dunussi‐Joannopoulos(4), Mark I. Furman(3), C. R. Valeri(3), Hak‐Ling Ma(3), Mayra Senices(3), Sean Keegan(3), Dean Messing(3), Mark E. Schnute(3), Michael J. Rohrer(3), Mark Ryan(3), Herbert B. Hechtman(2)