Mark Ryan

AbbVie (United States) — United States

Immunology and Microbiology · Life Sciences

15h-index1.5kcitations29works0.02yr avg
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Research Topics

Immune Cell Function and Interaction(9), T-cell and B-cell Immunology(8), Monoclonal and Polyclonal Antibodies Research(8), Bacterial Infections and Vaccines(7), Influenza Virus Research Studies(4)

Publications29 total

Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin
British Journal of Dermatology·2023· 29 citedOpen Access
Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free‐Energy Perturbation (FEP)
ChemMedChem·2015· 48 cited
Serine Protease HTRA1 Antagonizes Transforming Growth Factor-β Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation
PLoS ONE·2013· 70 citedOpen Access
Identification of Type‐II Inhibitors Using Kinase Structures
Chemical Biology & Drug Design·2012· 18 citedOpen Access
Syk Kinase Inhibitors
2012
Enhanced <scp>GITR</scp>/<scp>GITRL</scp> interactions augment <scp>IL</scp>‐27 expression and induce <scp>IL</scp>‐10‐producing Tr‐1 like cells
European Journal of Immunology·2012· 46 cited
IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Fas<i>lpr/lpr</i>/J Mice
The Journal of Immunology·2012· 79 citedOpen Access
Biophysical and Mechanistic Insights into Novel Allosteric Inhibitor of Spleen Tyrosine Kinase
Journal of Biological Chemistry·2012· 11 citedOpen Access
IL-21R is required for the systemic accumulation of activated B and T lymphocytes in MRL <i>lpr</i> mice (117.9)
The Journal of Immunology·2011
Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality
Journal of Leukocyte Biology·2010· 73 cited
Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody
Journal of Translational Medicine·2010· 3 citedOpen Access
Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys
Journal of Translational Medicine·2010· 19 citedOpen Access
Enhanced GITR/GITRL Interactions Augment IL-27 Production and Induce IL-10-producing Tr-1 Cells
Clinical Immunology·2010
Researchagonistic potential of a candidate therapeutic anti-IL21R antibody
2010
Glucocorticoid induced TNF Receptor Ligand (GITRL) transgenic mice develop T and B lymphocyte hyperplasia and expansion of CD4+ FOXP3+ cells
The FASEB Journal·2008
Sa.34. Interleukin-21 Receptor-deficient MRL-Faslpr Lupus Prone Mice Have Significantly Reduced B Cell-mediated Pathogenesis and Delayed Disease Progression
Clinical Immunology·2008
CCR8 Expression Identifies CD4 Memory T Cells Enriched for FOXP3+ Regulatory and Th2 Effector Lymphocytes
The Journal of Immunology·2006· 139 citedOpen Access
Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells
Gastroenterology·2003· 77 cited
Human and mouse intestinal epithelial cells (IEC) present glycolipid antigens to natural killer (NK)-T cells in a CD1d-restricted manner
Gastroenterology·2001· 2 cited
Activation of natural killer T cells by α-galactosylceramide in the presence of CD1d provides protection against colitis in mice
Gastroenterology·2000· 212 citedOpen Access
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Frequent Co-authors

Kingston H. G. Mills(8), Heath Guay(6), Deborah Young(6), Bernard P. Mahon(5), Laird Bloom(5), Quintus G. Medley(5), Mary Collins(5), Yijun Carrier(4), Nancy Stedman(4), Kyri Dunussi‐Joannopoulos(4), Richard S. Blumberg(3), Deborah Herber(3), Sean Keegan(3), Cheryl Nickerson‐Nutter(3), Stephen Benoit(3), Richard W. Pfeifer(3), Neelu Kaila(3), Atli Thorarensen(3), Joy Miyashiro(3), John Douhan(3)