Edward G. Lynn

University of California, San Francisco — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index1.4kcitations43works22.82yr avg
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Research Topics

Endoplasmic Reticulum Stress and Disease(8), Lipoproteins and Cardiovascular Health(5), Adipose Tissue and Metabolism(5), Cholesterol and Lipid Metabolism(5), Mitochondrial Function and Pathology(4)

Publications41 total

GDF10 is a negative regulator of vascular calcification
Journal of Biological Chemistry·2024· 1 citedOpen Access
Small molecules targeting GRP78 mitigate anti-GRP78 autoantibody–mediated tissue factor procoagulant activity in cultured endothelial cells
Journal of Thrombosis and Haemostasis·2024· 2 citedOpen Access
Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice
Journal of Biological Chemistry·2024· 3 citedOpen Access
Inhibitory Antibodies against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity
Kidney360·2022· 32 citedOpen Access
Scratching the Surface—An Overview of the Roles of Cell Surface GRP78 in Cancer
Biomedicines·2022· 20 citedOpen Access
4‐Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of <i>Apoe</i> <sup>−/−</sup> mice
The FASEB Journal·2019· 23 citedOpen Access
Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions
JCI Insight·2018· 48 citedOpen Access
Restoration of hepatic TDAG51 expression improves insulin signaling and reduces weight gain in mouse models of non‐alcoholic fatty liver disease
The FASEB Journal·2018· 1 cited
GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin‐induced pulmonary fibrosis
The Journal of Pathology·2016· 115 citedOpen Access
4-PBA-treated drinking water protects against atherosclerotic lesion growth in apoE-/- mice.
Atherosclerosis·2014
Abstract 655: 4-Phenylbutyrate in Drinking Water Reduced Atherosclerotic Lesion Growth in ApoE-/- Mice by Modifying Monocyte-Macrophage Differentiation
Arteriosclerosis Thrombosis and Vascular Biology·2014
Deficiency of TDAG51 Protects Against Atherosclerosis by Modulating Apoptosis, Cholesterol Efflux, and Peroxiredoxin‐1 Expression
Journal of the American Heart Association·2013· 36 citedOpen Access
Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis
Diabetes·2012· 40 citedOpen Access
Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPARα/PGC1α and thermogenic glycerolipid/fatty acid cycling
Physiological Genomics·2011· 24 cited
Hydrogen sulfide in the pathogenesis of atherosclerosis and its therapeutic potential
Expert Review of Clinical Pharmacology·2010· 51 cited
Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions
The FASEB Journal·2010· 49 cited
TNFα protects cardiac mitochondria independently of its cell surface receptors
Basic Research in Cardiology·2010· 43 cited
Transient upregulation of PGC-1α diminishes cardiac ischemia tolerance via upregulation of ANT1
Journal of Molecular and Cellular Cardiology·2010· 34 citedOpen Access
he role of lipoprotein-X in the development of glomerulosclerosis in familial LCAT deficienty
Open Collections·2009Open Access
SIRT2 is a negative regulator of anoxia–reoxygenation tolerance via regulation of 14‐3‐3 ζ and BAD in H9c2 cells
FEBS Letters·2008· 86 citedOpen Access
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Frequent Co-authors

Richard C. Austin(15), Šárka Lhoták(10), O Karmin(9), Michael N. Sack(7), Jae Hyun Byun(7), Yaw L. Siow(6), Jack Chen(5), Joan C. Krepinsky(5), Jeffrey G. Dickhout(4), Ricky Y.K. Man(4), Khrystyna Platko(4), Paul Lebeau(4), Kenneth N. Maclean(4), Melissa E. MacDonald(4), Tamana Yousof(4), Max Hamburgh(3), Bobby Shayegan(3), Gregory R. Steinberg(3), Suleiman A. Igdoura(3), Peter J. Munson(2)