Melissa E. MacDonald

McMaster University — Canada

Medicine · Health Sciences

14h-index706citations27works1.22yr avg
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Research Topics

Liver Disease Diagnosis and Treatment(5), Lipoproteins and Cardiovascular Health(5), Cholesterol and Lipid Metabolism(5), Chronic Kidney Disease and Diabetes(4), Parathyroid Disorders and Treatments(4)

Publications27 total

Follistatin improves vascular function by inhibiting oxidative stress and inducing browning of perivascular adipose tissue in essential hypertension
2026Open Access
miR-299a-5p is a mediator of fibrosis in diabetic kidney disease by regulating follistatin and cripto-1
Communications Biology·2025Open Access
GDF10 is a negative regulator of vascular calcification
Journal of Biological Chemistry·2024· 1 citedOpen Access
Follistatin lowers blood pressure and improves vascular structure and function in essential and secondary hypertension
Hypertension Research·2024· 3 cited
Abstract P448: Follistatin Improves Vascular Function by Regulating Perivascular Adipose Tissue in Essential Hypertension
Hypertension·2024
Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice
Journal of Biological Chemistry·2024· 3 citedOpen Access
Both sexes develop DKD in the CD1 uninephrectomized streptozotocin mouse model
Scientific Reports·2023· 5 citedOpen Access
Abstract P3001: Regulation Of Perivascular Adipose Tissue By Follistatin In Hypertension
Circulation Research·2023
A Metabolic Enhancer Protects against Diet-Induced Obesity and Liver Steatosis and Corrects a Pro-Atherogenic Serum Profile in Mice
Nutrients·2023· 5 citedOpen Access
A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling
Cellular & Molecular Biology Letters·2023· 14 citedOpen Access
Extensive diet-induced atherosclerosis in scavenger receptor class B type 1-deficient mice is associated with substantial leukocytosis and elevated vascular cell adhesion molecule-1 expression in coronary artery endothelium
Frontiers in Physiology·2023· 3 citedOpen Access
Inhibitory Antibodies against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity
Kidney360·2022· 32 citedOpen Access
Scratching the Surface—An Overview of the Roles of Cell Surface GRP78 in Cancer
Biomedicines·2022· 20 citedOpen Access
Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance
Nature Communications·2022· 106 citedOpen Access
The CARD14 Variant Rs11652075 Interacts with Vitamin D3 to Confer Barrier Dysfunction and Atopic Dermatitis Risk
Journal of Allergy and Clinical Immunology·2022
TDAG51 induces renal interstitial fibrosis through modulation of TGF-β receptor 1 in chronic kidney disease
Cell Death and Disease·2021· 17 citedOpen Access
miR299a-5p promotes renal fibrosis by suppressing the antifibrotic actions of follistatin
Scientific Reports·2021· 12 citedOpen Access
TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells
Arteriosclerosis Thrombosis and Vascular Biology·2020· 15 citedOpen Access
Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles
Cell Reports·2020· 90 citedOpen Access
Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice
JHEP Reports·2019· 79 citedOpen Access
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Frequent Co-authors

Richard C. Austin(14), Joan C. Krepinsky(13), Jae Hyun Byun(10), Paul Lebeau(9), Khrystyna Platko(9), Suleiman A. Igdoura(9), Bernardo L. Trigatti(7), Bo Gao(7), Nabil G. Seidah(5), Jeffrey G. Dickhout(5), Tamana Yousof(4), Edward G. Lynn(4), Ann Kuganathan(4), Šárka Lhoták(3), Kenneth N. Maclean(3), Vincent Lu(3), Gregory R. Steinberg(2), Mark A. Tarnopolsky(2), Aurora Mejía‐Benítez(2), Mark Fuller(2)