William James

University of Oxford — United Kingdom

Medicine · Health Sciences

61h-index17.9kcitations248works6.32yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(59), HIV Research and Treatment(47), COVID-19 Clinical Research Studies(26), Neuroinflammation and Neurodegeneration Mechanisms(21), Mosquito-borne diseases and control(19)

Publications244 total

Nanobodies against the S2 region of the spike protein potently neutralize SARS-CoV-2 viruses and show resistance to virus escape
2026Open Access
Development of a Recombinant Single-Cycle Influenza Viral Vector as an Intranasal Vaccine against SARS-CoV-2 and SARS-like Betacoronaviruses
2025Open Access
Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesicles
2025Open Access
Determination of resilience of a panel of broadly neutralizing mAbs to emerging variants of SARS-CoV-2 generated using reverse genetics
iScience·2025· 2 citedOpen Access
Publisher Correction: The molecular reach of antibodies crucially underpins their viral neutralisation capacity
Nature Communications·2025Open Access
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
Nature Communications·2025· 11 citedOpen Access
Antiviral and Immunomodulatory Effects of Zafirlukast Against Flaviviruses via Inhibition of the TNF Signaling Pathway
Journal of Medical Virology·2024Open Access
Anti-viral and immunomodulatory effects of Zafirlukast against flaviviruses via inhibition of the TNF signaling pathway
2024Open Access
Targeting glucose metabolism with dichloroacetate (DCA) reduces zika virus replication in brain cortical progenitors at different stages of maturation
Antiviral Research·2024· 1 cited
Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2
Open Biology·2024· 7 citedOpen Access
Proactive vaccination using multiviral Quartet Nanocages to elicit broad anti-coronavirus responses
Nature Nanotechnology·2024· 55 citedOpen Access
Author response for "Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2"
2024
Reviews of "Protective Non-neutralizing mAbs Ab94 and Ab81 Retain High-affinity and Potent Fc-mediated Function Against SARS-CoV-2 Variants from Omicron to XBB1.5"
2023Open Access
Review 2: "Protective Non-neutralizing mAbs Ab94 and Ab81 Retain High-affinity and Potent Fc-mediated Function Against SARS-CoV-2 Variants from Omicron to XBB1.5"
2023Open Access
Human microglia, microglial LRRK2, and tau pathogenesis: a complex relationship
Alzheimer s & Dementia·2023Open Access
Author response for "Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2"
2023
Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency
2023· 2 citedOpen Access
Hypoxia dampens innate immune signalling at early time points and increases Zika virus RNA levels in iPSC-derived macrophages
Journal of General Virology·2023· 2 citedOpen Access
Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy
Biology Open·2023· 8 citedOpen Access
Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology
2023· 13 citedOpen Access
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Frequent Co-authors

Sally A. Cowley(14), Miles W. Carroll(11), Christina Dold(9), Paul Klenerman(9), Donal Skelly(8), Alexander J. Mentzer(7), Julian C. Knight(7), Eleanor Barnes(7), Juthathip Mongkolsapaya(7), Gavin Screaton(7), Michael L. Knight(7), Javier Gilbert‐Jaramillo(6), Daming Zhou(5), Yuguang Zhao(5), Helen M. E. Duyvesteyn(5), Tao Dong(5), Jingshan Ren(5), David I. Stuart(5), Richard Wade‐Martins(5), Tiong Kit Tan(5)