Leanna Troncoso

Icahn School of Medicine at Mount Sinai — United States

Immunology and Microbiology · Life Sciences

10h-index2.0kcitations31works11.32yr avg
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Research Topics

Immune cells in cancer(13), Immune Cell Function and Interaction(10), Cancer Immunotherapy and Biomarkers(9), Immunotherapy and Immune Responses(7), Phagocytosis and Immune Regulation(7)

Publications31 total

788 Local type 2 stromal-myeloid signalling axis drives progression and immunotherapy resistance of colorectal cancer metastasis
Regular and Young Investigator Award Abstracts·2025Open Access
TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma
2025Open Access
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
Nature·2025· 9 cited
Multiparametric cellular and spatial organization in cancer tissue lesions with a streamlined pipeline
Nature Biomedical Engineering·2025· 3 citedOpen Access
MARQO pipeline resolves multiparametric cellular and spatial organization in cancer tissue lesions
2025Open Access
Abstract CT106: A phase 1b/2 trial of dupilumab given in conjunction with PD-1 or PD-L1 blockade and anakinra in the treatment of relapsed/refractory metastatic NSCLC
Cancer Research·2025
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Nature Immunology·2025· 30 cited
Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer
2024· 10 citedOpen Access
902 Hematopoietic aging promotes cancer by fueling IL-1α-driven emergency myelopoiesis
Regular and Young Investigator Award Abstracts·2024· 3 citedOpen Access
868 AXL restricts cholesterol mobilization, modulating dendritic cell maturation and the immune response to cancer
Regular and Young Investigator Award Abstracts·2024Open Access
Abstract PR-10: AXL limits the mobilization of cholesterol to regulate dendritic cell maturation and the immunogenic response to cancer
Cancer Immunology Research·2024
Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis
Science·2024· 96 citedOpen Access
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors
2024· 6 citedOpen Access
Spatial Molecular Profiling of the Kidney of Children with Lupus Nephritis
The Journal of Immunology·2024
AXL limits the mobilization of cholesterol to regulate dendritic cell maturation and the immunogenic response to cancer
2023· 7 citedOpen Access
An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis
Nature·2023· 158 citedOpen Access
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders
Immunity·2023· 39 citedOpen Access
650 Neoadjuvant ezabenlimab or pembrolizumab in combination with an anti-SIRPα antibody in resectable colorectal cancer
Regular and Young Investigator Award Abstracts·2023Open Access
Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration
2023· 2 citedOpen Access
MERFISH data for "Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma"
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
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Frequent Co-authors

Thomas U. Marron(27), Miriam Mérad(27), Jessica Le Bérichel(25), Pauline Hamon(23), Matthew D. Park(22), Raphaël Mattiuz(16), Seunghee Kim‐Schulze(15), Brian D. Brown(14), Samarth Hegde(14), C. Hennequin(14), Meriem Belabed(14), Alexandra Tabachnikova(13), Darwin D’souza(13), Ephraim Kenigsberg(11), Assaf Magen(11), Travis Dawson(11), Steven Hamel(11), Mark Buckup(11), Sacha Gnjatic(11), Christie Chang(10)