Darwin D’souza

Icahn School of Medicine at Mount Sinai — United States

Medicine · Health Sciences

11h-index1.2kcitations48works10.02yr avg
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Research Topics

Multiple Myeloma Research and Treatments(14), Immune Cell Function and Interaction(11), Chemokine receptors and signaling(10), Immune cells in cancer(8), CAR-T cell therapy research(7)

Publications48 total

Impact of Gestational Maternal SARS-CoV-2 Infection on Neonatal Inflammatory Biomarkers
2025Open Access
Spatially resolved transcriptomics reveals immunosuppressive niches and clonal diversity in extramedullary disease in multiple myeloma refractory to immunotherapy
Blood·2025Open Access
Daratumumab-based quadruplet therapy in functional high-risk relapse/refractory multiple myeloma patients induces changes associated with CD8 T cell signaling, activation and expansion
Blood·2025
788 Local type 2 stromal-myeloid signalling axis drives progression and immunotherapy resistance of colorectal cancer metastasis
Regular and Young Investigator Award Abstracts·2025Open Access
TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma
2025Open Access
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
Nature·2025· 9 cited
Daratumumab-Based Quadruplet Therapy in Functional High-Risk RRMM (fRRMM) Patients Promotes CD8 T Cell Activation and Expansion in the Immune Microenvironment
Clinical Lymphoma Myeloma & Leukemia·2025
Su1968: SINGLE CELL ANALYSIS OF LESIONAL TISSUES IN ACUTE SEVERE ULCERATIVE COLITIS IDENTIFIES ENRICHMENT OF TH17-POLARIZED CELLS
Gastroenterology·2025
Abstract CT106: A phase 1b/2 trial of dupilumab given in conjunction with PD-1 or PD-L1 blockade and anakinra in the treatment of relapsed/refractory metastatic NSCLC
Cancer Research·2025
Abstract 5258: The immunomodulatory effects of daratumumab-based therapy on functional high-risk relapse/refractory multiple myeloma (fHRMM) patients enrolled in the MyDRUG trial
Cancer Research·2025
Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer
2024· 10 citedOpen Access
4.6 – 00114 Transcriptomic profile of gut T follicular helper cells during persistent HIV infection
Journal of Virus Eradication·2024Open Access
902 Hematopoietic aging promotes cancer by fueling IL-1α-driven emergency myelopoiesis
Regular and Young Investigator Award Abstracts·2024· 3 citedOpen Access
Myocardial infarction augments sleep to limit cardiac inflammation and damage
Nature·2024· 64 citedOpen Access
Gastrointestinal germinal center B cell depletion and reduction in IgA <sup>+</sup> plasma cells in HIV-1 infection
Science Immunology·2024· 4 citedOpen Access
Informing biologically relevant signal from spatial transcriptomic data
2024· 1 citedOpen Access
Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis
Science·2024· 96 citedOpen Access
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors
2024· 6 citedOpen Access
Gastrointestinal germinal center B cell depletion and reduction in IgA <sup>+</sup> plasma cells in HIV-1 infection
2024· 1 citedOpen Access
A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma
2024· 13 citedOpen Access
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Frequent Co-authors

Seunghee Kim‐Schulze(42), Travis Dawson(32), Sacha Gnjatic(26), Edgar Gonzalez‐Kozlova(19), Adeeb Rahman(19), Matthew D. Park(15), Reyka G. Jayasinghe(15), Hearn Jay Cho(15), Mark Hamilton(15), Miriam Mérad(14), Shaji Kumar(14), Pauline Hamon(13), Leanna Troncoso(13), Thomas U. Marron(13), Yered Pita-Juárez(13), Taxiarchis Kourelis(13), Manoj Bhasin(13), Samarth Hegde(12), Swati S. Bhasin(12), William Pilcher(12)