Roselyn J. Eisenberg

University of Pennsylvania — United States

Medicine · Health Sciences

76h-index19.5kcitations202works0.02yr avg
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Research Topics

Herpesvirus Infections and Treatments(174), Toxin Mechanisms and Immunotoxins(64), Virus-based gene therapy research(59), Cytomegalovirus and herpesvirus research(53), Monoclonal and Polyclonal Antibodies Research(51)

Publications202 total

Receptor Binding-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein D Permit Interaction with the gH/gL Complex to Activate Fusion
Viruses·2023· 8 citedOpen Access
Characterization of a Heparan Sulfate Octasaccharide That Binds to Herpes Simplex Virus Type 1 Glycoprotein D
UNC Libraries·2021· 2 citedOpen Access
Using Split Luciferase Assay and Anti-Herpes Simplex Virus Glycoprotein Monoclonal Antibodies To Predict a Functional Binding Site between gD and gH/gL
Journal of Virology·2021· 18 citedOpen Access
Localization of the Interaction Site of Herpes Simplex Virus Glycoprotein D (gD) on the Membrane Fusion Regulator, gH/gL
Journal of Virology·2020· 27 citedOpen Access
Dynamic organization of Herpesvirus glycoproteins on the viral envelope revealed by super-resolution microscopy
PLoS Pathogens·2019· 24 citedOpen Access
Saliva enhances infection of gingival fibroblasts by herpes simplex virus 1
PLoS ONE·2019· 16 citedOpen Access
Surface Plasmon Resonance Reveals Direct Binding of Herpes Simplex Virus Glycoproteins gH/gL to gD and Locates a gH/gL Binding Site on gD
Journal of Virology·2019· 48 citedOpen Access
Resolving the molecular gymnastics of the elusive herpes simplex fusion protein
Access Microbiology·2019Open Access
Using Antibodies and Mutants To Localize the Presumptive gH/gL Binding Site on Herpes Simplex Virus gD
Journal of Virology·2018· 17 citedOpen Access
Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs
PLoS Pathogens·2018· 32 citedOpen Access
Recent Insights Into the Structural Characterization of Herpes Simplex Virus Fusion protein, gB
Future Virology·2018Open Access
The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane
mBio·2017· 49 citedOpen Access
Super-resolution fluorescence microscopy reveals various patterns of glycoprotein organization on the surface of Herpes Simplex Virus 1 particles
HAL (Le Centre pour la Communication Scientifique Directe)·2017
Global sensing of the antigenic structure of herpes simplex virus gD using high-throughput array-based SPR imaging
PLoS Pathogens·2017· 28 citedOpen Access
Prophylactic Herpes Simplex Virus 2 (HSV-2) Vaccines Adjuvanted with Stable Emulsion and Toll-Like Receptor 9 Agonist Induce a Robust HSV-2-Specific Cell-Mediated Immune Response, Protect against Symptomatic Disease, and Reduce the Latent Viral Reservoir
Journal of Virology·2017· 30 citedOpen Access
Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs
Frontiers in Immunology·2016· 13 citedOpen Access
Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections
Cell·2016· 257 citedOpen Access
Regulation of Herpes Simplex Virus Glycoprotein-Induced Cascade of Events Governing Cell-Cell Fusion
Journal of Virology·2016· 32 citedOpen Access
Patient-Specific Neutralizing Antibody Responses to Herpes Simplex Virus Are Attributed to Epitopes on gD, gB, or Both and Can Be Type Specific
Journal of Virology·2015· 41 citedOpen Access
Using a split luciferase assay (SLA) to measure the kinetics of cell–cell fusion mediated by herpes simplex virus glycoproteins
Methods·2015· 36 citedOpen Access
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Frequent Co-authors

Gary H. Cohen(49), J. Charles Whitbeck(19), Manuel Ponce de Leon(14), Patricia G. Spear(10), Claude Krummenacher(10), Huan Lou(9), Doina Atanasiu(5), Deborah Long(5), Robert J. Geraghty(4), Rebecca I. Montgomery(4), Florent C. Bender(4), Ruliang Xu(4), Andrea Carfı́(4), Harvey M. Friedman(4), Anthony V. Nicola(4), Ekaterina E. Heldwein(3), Bernard Moss(3), Don C. Wiley(3), Tina M. Cairns(3), John D. Lambris(3)