Huan Lou

University of Pennsylvania — United States

Medicine · Health Sciences

32h-index3.6kcitations47works0.02yr avg
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Research Topics

Herpesvirus Infections and Treatments(37), Cytomegalovirus and herpesvirus research(15), Toxin Mechanisms and Immunotoxins(14), Virus-based gene therapy research(13), Poxvirus research and outbreaks(12)

Publications47 total

Molecular determinants of the interaction between HSV-1 glycoprotein D and heparan sulfate
Frontiers in Molecular Biosciences·2022· 16 citedOpen Access
Localization of the Interaction Site of Herpes Simplex Virus Glycoprotein D (gD) on the Membrane Fusion Regulator, gH/gL
Journal of Virology·2020· 27 citedOpen Access
Point Mutations in Retargeted gD Eliminate the Sensitivity of EGFR/EGFRvIII-Targeted HSV to Key Neutralizing Antibodies
Molecular Therapy — Methods & Clinical Development·2020· 22 citedOpen Access
Surface Plasmon Resonance Reveals Direct Binding of Herpes Simplex Virus Glycoproteins gH/gL to gD and Locates a gH/gL Binding Site on gD
Journal of Virology·2019· 48 citedOpen Access
Using Antibodies and Mutants To Localize the Presumptive gH/gL Binding Site on Herpes Simplex Virus gD
Journal of Virology·2018· 17 citedOpen Access
One-dimensional data augmentation using a wasserstein generative adversarial network with supervised signal
2018· 13 cited
Global sensing of the antigenic structure of herpes simplex virus gD using high-throughput array-based SPR imaging
PLoS Pathogens·2017· 28 citedOpen Access
Patient-Specific Neutralizing Antibody Responses to Herpes Simplex Virus Are Attributed to Epitopes on gD, gB, or Both and Can Be Type Specific
Journal of Virology·2015· 41 citedOpen Access
Dissection of the Antibody Response against Herpes Simplex Virus Glycoproteins in Naturally Infected Humans
Journal of Virology·2014· 70 citedOpen Access
Repertoire of Epitopes Recognized by Serum IgG from Humans Vaccinated with Herpes Simplex Virus 2 Glycoprotein D
Journal of Virology·2014· 32 citedOpen Access
Relationship between ouabain and asthenozoospermia
Journal of Huazhong University of Science and Technology [Medical Sciences]·2014· 4 cited
Mechanism of Neutralization of Herpes Simplex Virus by Antibodies Directed at the Fusion Domain of Glycoprotein B
Journal of Virology·2013· 57 citedOpen Access
Displacement of the C Terminus of Herpes Simplex Virus gD Is Sufficient To Expose the Fusion-Activating Interfaces on gD
Journal of Virology·2013· 24 citedOpen Access
The Membrane-Proximal Region (MPR) of Herpes Simplex Virus gB Regulates Association of the Fusion Loops with Lipid Membranes
mBio·2012· 28 citedOpen Access
Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1
PLoS Pathogens·2011· 184 citedOpen Access
Role of cAMP-responsive Element-binding Protein (CREB)-regulated Transcription Coactivator 3 (CRTC3) in the Initiation of Mitochondrial Biogenesis and Stress Response in Liver Cells
Journal of Biological Chemistry·2011· 75 citedOpen Access
Capturing the Herpes Simplex Virus Core Fusion Complex (gB-gH/gL) in an Acidic Environment
Journal of Virology·2011· 64 citedOpen Access
Structural Basis of Local, pH-Dependent Conformational Changes in Glycoprotein B from Herpes Simplex Virus Type 1
Journal of Virology·2010· 76 citedOpen Access
Herpes Simplex Virus Glycoprotein D Interferes with Binding of Herpesvirus Entry Mediator to Its Ligands through Downregulation and Direct Competition
Journal of Virology·2010· 62 citedOpen Access
Bimolecular Complementation Defines Functional Regions of Herpes Simplex Virus gB That Are Involved with gH/gL as a Necessary Step Leading to Cell Fusion
Journal of Virology·2010· 129 citedOpen Access
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Frequent Co-authors

Gary H. Cohen(39), Roselyn J. Eisenberg(37), J. Charles Whitbeck(28), Tina M. Cairns(15), Claude Krummenacher(10), Manuel Ponce de Leon(10), Doina Atanasiu(9), Wangfang Hou(6), Florent C. Bender(5), Ann H. Rux(5), Lydia Aldaz-Carroll(5), Neil Kaplowitz(5), Wan Ting Saw(5), Ekaterina E. Heldwein(4), Sharon H. Willis(4), Andrew Stolz(4), Anthony V. Nicola(3), Manuel Ponce-de-León(3), Isabelle Baribaud(3), Stuart N. Isaacs(3)