Thomas J. Jentsch

Leibniz-Forschungsinstitut für Molekulare Pharmakologie — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

108h-index37.3kcitations283works3.42yr avg
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Research Topics

Ion channel regulation and function(183), Ion Transport and Channel Regulation(78), Neuroscience and Neuropharmacology Research(74), Cardiac electrophysiology and arrhythmias(50), Cellular transport and secretion(22)

Publications283 total

Metabolic acidosis causes a Fanconi-like syndrome with intracellular trafficking defects and proximal tubule dysfunction
Science Translational Medicine·2026
A protective cGAMP-mediated anti-tumor immune response can proceed without LRRC8/VRAC channels
Journal of Biological Chemistry·2025Open Access
TMEM9 subunits as new molecular regulators of endosomal chloride/proton exchangers
Eurasian journal of applied biotechnology·2025Open Access
LRRC8/VRAC chloride and metabolite channels in signaling and volume regulation
Trends in Biochemical Sciences·2025· 4 citedOpen Access
Structural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)P2
Nature Structural & Molecular Biology·2025· 4 citedOpen Access
Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity
Nature Communications·2025· 5 citedOpen Access
Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P <sub>2</sub>
2025· 2 citedOpen Access
Renal proximal tubules are sensitive to metabolic acidosis
2024· 1 citedOpen Access
Mutations in <scp><i>CLCN6</i></scp> as a Novel Genetic Cause of Neuronal Ceroid Lipofuscinosis in Patients and a Murine Model
Annals of Neurology·2024· 7 citedOpen Access
LRRC8/VRAC volume-regulated anion channels are crucial for hearing
Journal of Biological Chemistry·2024· 4 citedOpen Access
Gain-of-function variants in CLCN7 cause hypopigmentation and lysosomal storage disease
Journal of Biological Chemistry·2024· 10 citedOpen Access
KCNQ5 Controls Perivascular Adipose Tissue–Mediated Vasodilation
Hypertension·2023· 6 cited
Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl−/H+ Exchanger ClC-7
Biomolecules·2023· 9 citedOpen Access
Molecular basis of ClC-6 function and its impairment in human disease
Science Advances·2023· 12 citedOpen Access
Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels
Cell Reports·2023· 23 citedOpen Access
KCNQ5 controls perivascular adipose tissue-mediated vasodilation
2023Open Access
ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution
The Journal of Cell Biology·2023· 30 citedOpen Access
Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination
Journal of Clinical Investigation·2023· 30 citedOpen Access
SLC26A1 is a major determinant of sulfate homeostasis in humans
Journal of Clinical Investigation·2023· 14 citedOpen Access
Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy
Journal of the American Society of Nephrology·2022· 20 citedOpen Access
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Frequent Co-authors

Michael Pusch(7), Valentin Stein(6), Michaela Schweizer(6), Klaus Steinmeyer(6), Anselm A. Zdebik(5), Björn C. Schroeder(5), Christian Kubisch(4), Michael R. Bösl(4), Thomas Friedrich(4), Tobias Stauber(4), Christian A. Hübner(4), Uwe Kornak(3), Florian Ullrich(3), Stefan Gründer(3), Alain Vandewalle(3), Rosa Planells‐Cases(3), Jens C. Fuhrmann(3), Stefanie Weinert(3), Frank Weinreich(2), Ortrud K. Steinlein(2)