Thomas J. Broekelmann

Washington University in St. Louis — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

36h-index3.9kcitations71works0.02yr avg
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Research Topics

Connective tissue disorders research(40), Protease and Inhibitor Mechanisms(24), Cell Adhesion Molecules Research(21), Williams Syndrome Research(7), Aortic aneurysm repair treatments(6)

Publications71 total

Multi‐organ phenotypes in mice lacking latent <scp>TGFβ</scp> binding protein 2 (<scp>LTBP2</scp>)
Developmental Dynamics·2023· 9 citedOpen Access
Targeting Epidermal Growth Factor Receptor to Stimulate Elastic Matrix Regenerative Repair
Tissue Engineering Part A·2023· 5 citedOpen Access
Deletion of type VIII collagen reduces blood pressure, increases carotid artery functional distensibility and promotes elastin deposition
Matrix Biology Plus·2021· 22 citedOpen Access
Abstract PR09: Pharmacologic targeting of Gq reveals new pathways in uveal melanoma
Cancer Research·2020· 1 cited
Identification of the growth factor–binding sequence in the extracellular matrix protein MAGP-1
Journal of Biological Chemistry·2020· 22 citedOpen Access
The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome
Function·2020· 23 citedOpen Access
Abstract 1764: Targeting nucleotide exchange to inhibit Gq/11 driver mutations in uveal melanoma
Cancer Research·2019
Abstract 1764: Targeting nucleotide exchange to inhibit Gq/11 driver mutations in uveal melanoma
Molecular and Cellular Biology / Genetics·2019
Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress
JCI Insight·2019· 19 citedOpen Access
Fibulin‐4 and Lysyl Oxidase Cooperate to Maintain Arterial Wall Integrity in Large but not Small Vessels
The FASEB Journal·2019
Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis
Cell Metabolism·2018· 47 citedOpen Access
Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells
Science Signaling·2018· 106 citedOpen Access
Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease
Matrix Biology·2018· 51 citedOpen Access
Contribution of metabolic disease to bone fragility in MAGP1-deficient mice
Matrix Biology·2018· 13 citedOpen Access
Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness
American Journal of Physiology-Heart and Circulatory Physiology·2018· 59 citedOpen Access
Measurement of elastin, collagen, and total protein levels in tissues
Methods in cell biology·2017· 76 cited
Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries
Science Advances·2017· 39 citedOpen Access
Fibulin‐4 Is Important for Maintaining Vascular Wall Integrity in Large but Not Small Vessels
The FASEB Journal·2017
Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness
American Journal of Physiology-Heart and Circulatory Physiology·2015· 24 citedOpen Access
Microfibril-associated Glycoprotein 2 (MAGP2) Loss of Function Has Pleiotropic Effects in Vivo
Journal of Biological Chemistry·2013· 68 citedOpen Access
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Frequent Co-authors

Robert P. Mecham(45), Robert M. Senior(6), Cláudio C. Werneck(6), Clarissa S. Craft(6), Russell H. Knutsen(6), Beth A. Kozel(5), Barbara Crippes Trask(5), Richard A. Pierce(5), Timothy M. Ritty(5), Patricia Brown‐Augsburger(4), Clarina Tisdale(4), Timothy M. Trask(4), Tracy L. Adair-Kirk(4), Wei Zou(4), Steven L. Teitelbaum(4), Howard G. Welgus(3), Barry Starcher(3), Fernando Segade(3), Pyong Woo Park(3), Elaine C. Davis(3)