Robert P. Mecham

Washington University in St. Louis — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

84h-index24.8kcitations406works0.72yr avg
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Research Topics

Connective tissue disorders research(229), Protease and Inhibitor Mechanisms(88), Cell Adhesion Molecules Research(55), Elasticity and Material Modeling(39), Aortic aneurysm repair treatments(37)

Publications403 total

Loss of MFAP5 and Its Effect on Skin Homeostasis and Wound Healing
The FASEB Journal·2025Open Access
Elastin Regulation of Vasoreactivity in Resistance Arteries
Hypertension·2025Open Access
Latent transforming growth factor binding protein-2 (LTBP2), an IPF biomarker of clinical decline, promotes TGF-beta signaling and lung fibrosis in mice
2025· 1 citedOpen Access
Lysostaphin
Handbook of Proteolytic Enzymes·2025
Collagens and Elastic Fiber Proteins in Lung Development
2024· 3 cited
Multi‐organ phenotypes in mice lacking latent <scp>TGFβ</scp> binding protein 2 (<scp>LTBP2</scp>)
Developmental Dynamics·2023· 9 citedOpen Access
Constitutive Modeling of Mouse Arteries Suggests Changes in Directional Coupling and Extracellular Matrix Remodeling That Depend on Artery Type, Age, Sex, and Elastin Amounts
Journal of Biomechanical Engineering·2023· 10 citedOpen Access
Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1
JCI Insight·2023· 8 citedOpen Access
Author Correction: SVEP1 is an endogenous ligand for the orphan receptor PEAR1
Nature Communications·2023· 1 citedOpen Access
DISTINCT PATTERNS OF SMOOTH MUSCLE PHENOTYPIC MODULATION IN THORACIC AND ABDOMINAL AORTIC ANEURYSM
Journal of the American College of Cardiology·2023· 1 citedOpen Access
SVEP1 is an endogenous ligand for the orphan receptor PEAR1
Nature Communications·2023· 28 citedOpen Access
A new mouse model of elastin haploinsufficiency highlights the importance of elastin to vascular development and blood pressure regulation
Matrix Biology·2023· 12 citedOpen Access
Targeting Epidermal Growth Factor Receptor to Stimulate Elastic Matrix Regenerative Repair
Tissue Engineering Part A·2023· 5 citedOpen Access
Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers replication stress and an aging-associated secretory signature
GeroScience·2022· 23 citedOpen Access
Increases in hydraulic conductance and solute permeability in a mouse model of ascending thoracic aortic aneurysm
Journal of Biomechanics·2022· 4 citedOpen Access
Polarized localization of phosphatidylserine in endothelium regulates Kir2.1
2022· 1 citedOpen Access
Mutation in the matricellular gene fibulin-4 leads to endothelial dysfunction in resistance arteries
2022· 1 citedOpen Access
The internal elastic lamina of resistance arteries facilitates vasodilation
The FASEB Journal·2022
Endothelial dysfunction drives aneurysm development in Marfan syndrome
The FASEB Journal·2022
Impacts of Microfibril-Associated Glycoprotein 1 and 2 Deficiency in Bleomycin-Induced Pulmonary Fibrosis
2022
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Frequent Co-authors

Thomas J. Broekelmann(9), Robert M. Senior(7), Gail L. Griffin(6), Jessica E. Wagenseil(5), Elaine C. Davis(5), Russell H. Knutsen(5), Howard G. Welgus(4), Kurt R. Stenmark(4), Barry Starcher(4), Dean Y. Li(3), Joel Rosenbloom(3), William C. Parks(3), David S. Wrenn(3), Aleksander Hinek(3), Steven D. Shapiro(3), Beth A. Kozel(3), Beth B. Boak(2), Mark T. Keating(2), William R. Abrams(2), Connie M. Ng(2)