Zulma Magnani

Vita-Salute San Raffaele University — Italy

Medicine · Health Sciences

18h-index2.8kcitations57works4.22yr avg
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Research Topics

CAR-T cell therapy research(32), Virus-based gene therapy research(27), CRISPR and Genetic Engineering(15), Hematopoietic Stem Cell Transplantation(14), Cytomegalovirus and herpesvirus research(10)

Publications57 total

Acute Myeloid Leukemia eradication targeting cathepsin g with a dual HLA-restricted TCR
Blood·2025
Abstract LB029: TIGIT deletion rescues the antitumor activity of low avidity T cells by increasing TCR signal strength
Cancer Research·2025
780 Treatment of ovarian cancer cells with olaparib and trabectedin modulates the expression of immune-related molecules and the killing ability of TCR-edited T cells
2024
1037 Adoptive cell therapy with genetically engineered t-cells for epithelial ovarian cancer
2024
TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells
Frontiers in Immunology·2024· 21 citedOpen Access
Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR
Science Advances·2023· 6 citedOpen Access
CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function
Science Translational Medicine·2022· 44 citedOpen Access
Flow cytometry data mining by cytoChain identifies determinants of exhaustion and stemness in TCR‐engineered T cells
European Journal of Immunology·2021· 15 citedOpen Access
Author response for "Flow cytometry data mining by cytoChain identifies determinants of exhaustion and stemness in TCR‐engineered T cells"
2021Open Access
CD4+ Memory Stem T Cells Recognizing Citrullinated Epitopes Are Expanded in Patients With Rheumatoid Arthritis and Sensitive to Tumor Necrosis Factor Blockade
Arthritis & Rheumatology·2019· 42 cited
Generation of Memory Stem T Cells Specific for Tumor Antigens and Resistant to Inhibitory Signals By Genome Editing
Blood·2018
NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease
Blood·2017· 82 citedOpen Access
752. Single Chain TCR Gene Editing in Adoptive Cell Therapy for Multiple Myeloma
Molecular Therapy·2016Open Access
Early recovery of CMV immunity after HLA-haploidentical hematopoietic stem cell transplantation as a surrogate biomarker for a reduced risk of severe infections overall
Bone Marrow Transplantation·2015· 11 cited
209. TCR Gene Editing in a Single Step of T Cell Activation To Redirect T Cell Specificity and Prevent GvHD
Molecular Therapy·2015Open Access
NY-ESO-1 Single Edited T Cells to Treat Multiple Myeloma without Inducing GvHD
Blood·2014
TCR Gene Editing Achieved In a Single Round Of T Cell Activation Is Sufficient To Redirect T Cell Specificity and Prevent GvHD
Blood·2013
Graft-versus-leukemia Effect of HLA-haploidentical Central-memory T-cells Expanded With Leukemic APCs and Modified With a Suicide Gene
Molecular Therapy·2013· 22 citedOpen Access
Early Reconstitution of T-Cell Immunity to CMV After HLA-Haploidentical Hematopoietic Stem Cell Transplantation Is a Strong Surrogate Biomarker for Lower Non-Relapse Mortality Rates
Blood·2012· 3 cited
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
Nature Medicine·2012· 438 citedOpen Access
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Frequent Co-authors

Chiara Bonini(44), Fabio Ciceri(36), Claudio Bordignon(30), Attilio Bondanza(28), Elena Provasi(17), Barbara Camisa(14), Massimo Bernardi(13), Jacopo Peccatori(13), Maurilio Ponzoni(13), Luigi Naldini(13), Maria Teresa Lupo Stanghellini(12), Catia Traversari(11), Marco Bregni(11), Pietro Genovese(11), Angelo Lombardo(11), Michael C. Holmes(11), Philip D. Gregory(10), Fulvio Crippa(9), Luca Vago(9), Monica Salomoni(8)