Fredrik R. Zetterberg

Galecto (Denmark) — Denmark

Immunology and Microbiology · Life Sciences

20h-index1.4kcitations66works7.52yr avg
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Research Topics

Galectins and Cancer Biology(53), Glycosylation and Glycoproteins Research(22), Peptidase Inhibition and Analysis(18), Signaling Pathways in Disease(8), Toxin Mechanisms and Immunotoxins(7)

Publications66 total

Pharmacological Characterization of GB1908, a Selective Galectin-1 Carbohydrate Binding Domain Inhibitor for the Treatment of Cancer
Pharmacology·2025· 3 cited
Development and Characterization of a High-Affinity Selective Galectin-3 Mouse Tool Compound in Mouse Models of Cancer
Journal of Medicinal Chemistry·2024· 2 cited
Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver
European Journal of Pharmacology·2024· 10 cited
Galectin-1 Induces the Production of Immune-Suppressive Cytokines in Human and Mouse T Cells
International Journal of Molecular Sciences·2024· 4 citedOpen Access
Sulfonamide-derivatized galactosides selectively target an unexplored binding site in the galectin-9N-terminal domain
Bioorganic & Medicinal Chemistry·2024· 1 citedOpen Access
Single‑Dose Pharmacokinetics and Safety of the Oral Galectin‑3 Inhibitor, Selvigaltin (GB1211), in Participants with Hepatic Impairment
Clinical Drug Investigation·2024· 7 cited
Relative bioavailability and food effect of the galectin-3 inhibitor selvigaltin (GB1211) administered as a tablet in healthy participants (GALBA-1)
Cancer Chemotherapy and Pharmacology·2024· 2 citedOpen Access
The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis
Frontiers in Pharmacology·2024· 9 citedOpen Access
Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance
International Journal of Molecular Sciences·2024· 1 citedOpen Access
Myocardin related transcription factor and galectin-3 drive lipid accumulation in human blood vessels
Vascular Pharmacology·2024
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
Journal of Medicinal Chemistry·2024· 26 citedOpen Access
Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis
Journal of Biological Chemistry·2024· 24 citedOpen Access
Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance
Preprints.org·2024· 2 citedOpen Access
Interplay of halogen bonding and solvation in protein–ligand binding
iScience·2024· 21 citedOpen Access
Myocardin Related Transcription Factor and Galectin-3 Drives Lipid Accumulation in Human Blood Vessels
SSRN Electronic Journal·2024Open Access
Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Models of Corneal Wound Healing
American Journal Of Pathology·2023· 2 citedOpen Access
Discovery of Selective and Orally Available Galectin-1 Inhibitors
Journal of Medicinal Chemistry·2023· 19 citedOpen Access
Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis
2023· 1 citedOpen Access
Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1
Frontiers in Immunology·2023· 29 citedOpen Access
Abstract LB104: Preclinical evaluation of the role of Galectin-1 in tumor immune evasion associated mechanisms using a highly selective Galectin-1 small molecule inhibitor
Cancer Research·2023· 1 cited
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Frequent Co-authors

Ulf J. Nilsson(29), Hakon Leffler(27), Robert J. Slack(18), Alison C. MacKinnon(15), Kristoffer Peterson(14), James A. Roper(11), Anders N. Pedersen(10), Hans Schambye(9), Barbro Kahl-Knutson(9), Ian Holyer(8), Lise Gravelle(7), Susan Tantawi(6), M. Håkansson(6), Peter Bach(5), Duncan C. Humphries(4), Derek T. Logan(4), J.J.J. van Giezen(4), Kimberly D. Herman(4), Anders Kirstein Pedersen(4), Paul Ford(3)