Jerry L. Spivak

Johns Hopkins University — United States

Medicine · Health Sciences

57h-index11.4kcitations322works0.32yr avg
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Research Topics

Myeloproliferative Neoplasms: Diagnosis and Treatment(141), Acute Myeloid Leukemia Research(63), Erythropoietin and Anemia Treatment(53), Erythrocyte Function and Pathophysiology(45), Hemoglobinopathies and Related Disorders(43)

Publications322 total

Thrombopoietin inhibition abrogates JAK2V617F clonal expansion in a murine model of myeloproliferative neoplasm
Blood·2025Open Access
HMGA1 chromatin regulators drive transcriptional networks involved in megakaryocyte expansion, fibrosis, and sensitivity to interferon signaling in JAK2-V617F MPN
Blood·2025Open Access
Conflating polycythemia vera with essential thrombocytosis
Blood Advances·2025· 1 citedOpen Access
Abstract 1432: HMGA1 disrupts 3D genome architecture and chromatin looping to repress MHC-II genes and drive immune evasion
Cancer Research·2025
Myeloproliferative Neoplasms: Challenging Dogma
Journal of Clinical Medicine·2024· 1 citedOpen Access
HMGA1 Chromatin Regulators Disrupt 3D Genome Architecture and Chromatin Looping to Repress MHC II Genes and Drive Immune Evasion during MPN Progression
Blood·2024
Abstract 2631: HMGA1 chromatin regulators drive immune evasion in myeloproliferative neoplasms by repressing gene networks involved in antigen presentation
Cancer Research·2024
Single Cell Transcriptomics Reveal That HMGA1 Chromatin Regulators Drive Transcriptional Networks Involved in Megakaryocyte Expansion, Platelet Activation, and Interferon Signaling in <i>JAK2 V617F</i> Myeloproliferative Neoplasms
Blood·2023· 1 citedOpen Access
A c- <i>MPL</i> Splice Variant up-Regulated in Myeloproliferative Neoplasms Modulates Thrombopoietin Signaling and Induces Cycling of Hematopoietic Stem Cells and Inflammatory Progenitors
Blood·2023
HMGA1 Chromatin Regulators Drive Immune Evasion in MPN Progression through Epigenetic Rewiring to Repress Antigen Presentation
Blood·2023· 2 cited
The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation
Blood·2022
Review of: "Potential limitations of diagnostic standard codes to distinguish polycythemia vera and secondary erythrocytosis"
2022· 1 citedOpen Access
HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression
Blood·2022· 43 citedOpen Access
The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation and Immune Attack
Blood·2021
HMGA1 Chromatin Regulators Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce Networks Involved in GATA2 and Proliferation
Blood·2021
Advances in polycythemia vera and lessons for acute leukemia
Best Practice & Research Clinical Haematology·2021· 5 cited
Abstract 2666: HMGA1: An epigenetic switch required for MPN progression by inducing <i>GATA-2</i> and cell cycle progression through enhancer rewiring
Cancer Research·2021
Are polycythemia vera, essential thrombocytosis, and primary myelofibrosis 1, 2, or 3 diseases?
Leukemia·2021· 5 cited
The Thrombopoietin Receptor, MPL, Is a Therapeutic Target of Opportunity in the MPN
Frontiers in Oncology·2021· 8 citedOpen Access
Sex determines the presentation and outcomes in MPN and is related to sex-specific differences in the mutational burden
Blood Advances·2020· 62 citedOpen Access
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Frequent Co-authors

Alison R. Moliterno(11), Donna M. Williams(8), Ophelia Rogers(6), Sanford J. Shattil(3), E HENDERSON(3), J. Douglas Rizzo(2), Melissa Brouwers(2), Patricia A. Hurley(2), Jerome Seidenfeld(2), Murat O. Arcasoy(2), Julia Bohlius(2), Darren Evanchuk(2), Matthew J. Goode(2), Ann A. Jakubowski(2), David H. Regan(2), Mark R. Somerfield(2), Damiano Rondelli(2), Giovanni Barosi(2), L BOXER(2), Roxann Ingersoll(2)