Sanford J. Shattil

University of California, San Diego — United States

Medicine · Health Sciences

96h-index30.6kcitations318works2.02yr avg
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Research Topics

Cell Adhesion Molecules Research(144), Platelet Disorders and Treatments(137), Blood properties and coagulation(37), Blood groups and transfusion(28), Monoclonal and Polyclonal Antibodies Research(26)

Publications317 total

Talin, a Rap1 effector for integrin activation at the plasma membrane, also promotes Rap1 activity by disrupting sequestration of Rap1 by SHANK3
Journal of Cell Science·2025· 2 citedOpen Access
Platelet SHARPIN regulates platelet adhesion and inflammatory responses through associations with αIIbβ3 and LUBAC
Blood Advances·2022· 10 citedOpen Access
Cancer-Associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
PubMed·2021· 152 cited
Relationships between Rap1b, Affinity Modulation of Integrin α IIb β 3 , and the Actin Cytoskeleton
UNC Libraries·2021Open Access
Genetic Instruction of Megakaryocytes and Platelets Derived from Human Induced Pluripotent Stem Cells for Studies of Integrin Regulation
Methods in molecular biology·2020· 2 cited
Primary Megakaryocytes Reveal a Role for Transcription Factor Nf-E2 in Integrin αiibβ3 Signaling
UNC Libraries·2020Open Access
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia
Nucleic Acid Therapeutics·2020· 27 cited
Studies of Integrin Signaling Through Platelet αIIbβ3
2019
SHARPIN at the nexus of integrin, immune, and inflammatory signaling in human platelets
Proceedings of the National Academy of Sciences·2019· 42 citedOpen Access
uPAR isoform 2 forms a dimer and induces severe kidney disease in mice
Journal of Clinical Investigation·2019· 65 citedOpen Access
NCCN Guidelines Insights: Cancer-Associated Venous Thromboembolic Disease, Version 2.2018
Journal of the National Comprehensive Cancer Network·2018· 241 citedOpen Access
Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation
Blood Advances·2018· 33 citedOpen Access
Optogenetic interrogation of integrin αVβ3 function in endothelial cells
Journal of Cell Science·2017· 23 citedOpen Access
Regulation of Platelet Adhesion Receptors
2017· 7 cited
Blood's 70th anniversary: musings of a Blood editor, 2003-2007
Blood·2016Open Access
Integrin-based therapeutics: biological basis, clinical use and new drugs
Nature Reviews Drug Discovery·2016· 399 citedOpen Access
Role forADAP in shearflow-induced platelet mechanotransduction
2016
Cancer-Associated Venous Thromboembolic Disease, Version 1.2015
Journal of the National Comprehensive Cancer Network·2015· 216 cited
Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor
Blood·2015· 34 citedOpen Access
Abstract 4240: Targeting Galectin-3 to reverse tumor stemness and drug resistance
Cancer Research·2014
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Frequent Co-authors

Mark H. Ginsberg(15), Joan S. Brugge(7), Nisar A. Pampori(4), Timothy E. O’Toole(4), Richard A. Cooper(4), Koji Eto(3), David Calderwood(3), Therese Wiedmer(3), Zaverio M. Ruggeri(3), Paul E. Hughes(3), James A. Hoxie(2), Michael Cunningham(2), Peter J. Sims(2), Marshall A. Lichtman(2), Jeffrey M. Spivak(2), L BOXER(2), Chinten James Lim(2), Wilma Puzon-McLaughlin(2), Miller Huang(2), Joseph B. Bolen(2)