James A. Hoxie

California University of Pennsylvania — United States

Immunology and Microbiology · Life Sciences

80h-index20.7kcitations221works0.32yr avg
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Research Topics

HIV Research and Treatment(151), Immune Cell Function and Interaction(91), HIV/AIDS drug development and treatment(39), T-cell and B-cell Immunology(36), Monoclonal and Polyclonal Antibodies Research(24)

Publications221 total

Depletion and recovery of IgG following treatment with Rozanoliximab and Imlifidase in pigtail macaques
2025Open Access
Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect
The Journal of Experimental Medicine·2025Open Access
The Impact of SIV-Induced Immunodeficiency on SARS-CoV-2 Disease, Viral Dynamics, and Antiviral Immune Response in a Nonhuman Primate Model of Coinfection
Viruses·2024· 1 citedOpen Access
The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection
2023Open Access
HIV-1–Infected CD4+ T Cells Present MHC Class II–Restricted Epitope via Endogenous Processing
The Journal of Immunology·2022· 7 citedOpen Access
A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection
PLoS Pathogens·2022· 6 citedOpen Access
Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4
PLoS Pathogens·2022· 15 citedOpen Access
The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease
PLoS Pathogens·2021· 18 citedOpen Access
The pigtail macaque ( <i>Macaca nemestrina</i> ) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease
2021· 4 citedOpen Access
A tyrosine-based trafficking signal in the simian immunodeficiency virus envelope cytoplasmic domain is strongly selected for in pathogenic SIV infection
2021· 1 citedOpen Access
V3 Loop Truncations in HIV-1 Envelope Impart Resistance to Coreceptor Inhibitors and Enhanced Sensitivity to Neutralizing Antibodies
UNC Libraries·2020Open Access
Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo
Nature Medicine·2020· 121 citedOpen Access
Tetherin downmodulation by SIVmac Nef lost with the H196Q escape variant is restored by an upstream variant
PLoS ONE·2020· 4 citedOpen Access
Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8 <sup>+</sup> T cells
Science Translational Medicine·2019· 121 citedOpen Access
Mechanisms of reactivation of latent tuberculosis infection due to SIV coinfection
Journal of Clinical Investigation·2019· 70 citedOpen Access
CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo
UNC Libraries·2019Open Access
Extended CCR5 Blockade for Graft-versus-Host Disease Prophylaxis Improves Outcomes of Reduced-Intensity Unrelated Donor Hematopoietic Cell Transplantation: A Phase II Clinical Trial
Biology of Blood and Marrow Transplantation·2018· 31 cited
Polymorphisms in Rhesus Macaque Tetherin Are Associated with Differences in Acute Viremia in Simian Immunodeficiency Virus Δ <i>nef</i> -Infected Animals
Journal of Virology·2018· 7 citedOpen Access
HIV-1 latent reservoir size and diversity are stable following brief treatment interruption
Journal of Clinical Investigation·2018· 110 citedOpen Access
The SIV Envelope Glycoprotein, Viral Tropism, and Pathogenesis: Novel Insights from Nonhuman Primate Models of AIDS
Current HIV Research·2017· 12 cited
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Frequent Co-authors

Lawrence F. Brass(10), Robert W. Doms(8), Beth Haggarty(5), Mark Marsh(4), M Ahuja(4), Anthony S. Fauci(4), George M. Shaw(4), Elizabeth Belmonte(4), Celia C. LaBranche(4), Frédéric Baribaud(4), Julie D. Turner(3), Patricia J. Vance(3), John R. Mascola(3), Dennis D. Taub(3), Richard Horuk(3), Joseph Hesselgesser(3), Stephen C. Peiper(3), James E. Robinson(3), Trevor L. Hoffman(3), Sanford J. Shattil(2)