John R. Mascola

University of North Carolina at Chapel Hill — United States

Immunology and Microbiology · Life Sciences

153h-index84.5kcitations777works5.02yr avg
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Research Topics

HIV Research and Treatment(520), Immune Cell Function and Interaction(226), Monoclonal and Polyclonal Antibodies Research(184), HIV/AIDS drug development and treatment(157), T-cell and B-cell Immunology(102)

Publications772 total

Potent Monoclonal Antibodies Against Circulating Yellow Fever Virus Strains from Donors Immunized with the 17D Vaccine
American Journal of Tropical Medicine and Hygiene·2025Open Access
MDX2003, a novel tetraspecific T cell engager-expander targeting CD19xCD20xCD3xCD28, demonstrates potent preclinical activity against B cell malignancies
Blood·2025
1156 MDX2004, a novel immune rejuvenator targeting CD3, CD28, and 4–1BB, augments tumor immunity in preclinical animal models
Regular and Young Investigator Award Abstracts·2025Open Access
Human Coronavirus HKU1 Neutralizing Monoclonal Antibodies Target Diverse Epitopes Within and Around the TMPRSS2 Receptor Binding Site
2025Open Access
Stable Latent HIV Infection and Low-level Viremia Despite Treatment With the Broadly Neutralizing Antibody VRC07-523LS and the Latency Reversal Agent Vorinostat
UNC Libraries·2025Open Access
Improved targeting and elicitation of VRC01-class precursors by an optimized glycan-masking mutant of OD-GT8
2025Open Access
Systemic and Mucosal Humoral Immune Responses to Lumazine Synthase 60-mer Nanoparticle SARS-CoV-2 Vaccines
Vaccines·2025· 1 citedOpen Access
Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies
The Journal of Experimental Medicine·2025· 5 citedOpen Access
Pharmacokinetics Analysis of Serum and Rectal Tissue Concentrations of a Pair of Anti‐HIV Monoclonal Antibodies, VRC01 and VRC01LS, in Adults Without HIV
The Journal of Clinical Pharmacology·2025Open Access
A phase 1/2a, multicenter, first-in-human, open-label clinical trial evaluating MDX2001, a tetraspecific T cell engager-expander in patients with advanced solid tumors.
Journal of Clinical Oncology·2025· 1 cited
Novel HIV-1 fusion peptide immunogens using glycan-engineered alphavirus-like particles
2025Open Access
Virologic effects of broadly neutralizing antibodies VRC01LS and VRC07-523LS on chronic HIV-1 infection
JCI Insight·2025· 6 citedOpen Access
Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350
Immunity·2025· 7 citedOpen Access
Pre-exposure antibody prophylaxis protects macaques from severe influenza
Science·2025· 10 cited
Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition
UNC Libraries·2025Open Access
A MERS-CoV antibody neutralizes a pre-emerging group 2c bat coronavirus
UNC Libraries·2025Open Access
A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies
Cell Reports·2024· 5 citedOpen Access
Enhanced and sustained biodistribution of HIV-1 neutralizing antibody VRC01LS in human genital and rectal mucosa
Nature Communications·2024· 4 citedOpen Access
Structure-based design of glycoprotein subunit vaccines for mumps
Proceedings of the National Academy of Sciences·2024· 4 citedOpen Access
1287 Preclinical characterization of MDX2001, a novel tetraspecific T cell engager (CD3/CD28) targeting TROP2 and c-MET in solid tumor malignancies
Regular and Young Investigator Award Abstracts·2024Open Access
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Frequent Co-authors

Peter D. Kwong(20), Barney S. Graham(17), Nicole A. Doria‐Rose(15), Mark K. Louder(13), Sijy O’Dell(12), Tongqing Zhou(12), Stephen D. Schmidt(11), Gary J. Nabel(11), Julie E. Ledgerwood(10), Mark Connors(10), Ivelin S. Georgiev(9), Yongping Yang(9), David C. Montefiori(9), Baoshan Zhang(9), Barton F. Haynes(9), Wei Shi(8), Robert T. Bailer(8), Adrian B. McDermott(7), Richard T. Wyatt(7), Lawrence Shapiro(7)