Richard T. Wyatt

Scripps Research Institute — United States

Immunology and Microbiology · Life Sciences

83h-index32.7kcitations209works2.82yr avg
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Research Topics

HIV Research and Treatment(193), Immune Cell Function and Interaction(102), Monoclonal and Polyclonal Antibodies Research(94), T-cell and B-cell Immunology(44), HIV/AIDS drug development and treatment(43)

Publications209 total

Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk
Nature Communications·2025· 3 citedOpen Access
HIV Env trimers elicit NHP apex cross-neutralizing antibodies mimicking human bNAbs
2025· 1 citedOpen Access
Accelerated cGMP production of near-native HIV-1 Env trimers following electroporation transfection and immunogenicity analysis
npj Vaccines·2025· 1 citedOpen Access
Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response
Nature Communications·2025Open Access
Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer
Immunity·2025· 3 cited
Molecular parameters governing antibody FcγR signaling and effector functions in the context of HIV envelope
Cell Reports·2025· 3 citedOpen Access
Antigen Dose and Persistence Contribute to Induction of a Durable HIV-1-Specific Neutralizing Antibody Response
2024Open Access
mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies
Frontiers in Immunology·2024· 11 citedOpen Access
Modulation of immune responses to liposomal vaccines by intrastructural help
European Journal of Pharmaceutics and Biopharmaceutics·2023· 3 citedOpen Access
Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response
Frontiers in Immunology·2023· 7 citedOpen Access
Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes
Pharmaceutics·2022· 4 citedOpen Access
Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization
PLoS Pathogens·2021· 8 citedOpen Access
Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization
2021· 1 citedOpen Access
Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity
Cell Reports·2020· 145 citedOpen Access
Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization
Cell Reports·2019· 50 citedOpen Access
Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses
The Journal of Experimental Medicine·2019· 31 citedOpen Access
Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability
Immunity·2019· 139 citedOpen Access
Calcium Phosphate Nanoparticle-Based Vaccines as a Platform for Improvement of HIV-1 Env Antibody Responses by Intrastructural Help
Nanomaterials·2019· 26 citedOpen Access
Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment
mBio·2019· 14 citedOpen Access
Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease
Nature Immunology·2019· 108 cited
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Frequent Co-authors

Joseph Sodroski(29), Peter D. Kwong(26), John R. Mascola(14), Dennis R. Burton(12), James E. Robinson(9), Wayne A. Hendrickson(9), William R. Schief(8), Mark Connors(8), Ian A. Wilson(7), Yuxing Li(6), Sijy O’Dell(6), Mark K. Louder(6), Andrew B. Ward(6), Stephen A. Migueles(6), Xueling Wu(5), Tongqing Zhou(5), Nicole A. Doria‐Rose(5), Gary J. Nabel(5), Marie Pancera(5), Xinzhen Yang(5)