David C. Montefiori

University of North Carolina at Chapel Hill — United States

Immunology and Microbiology · Life Sciences

142h-index85.8kcitations1.2kworks6.52yr avg
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Research Topics

HIV Research and Treatment(921), Immune Cell Function and Interaction(361), HIV/AIDS drug development and treatment(190), Immunotherapy and Immune Responses(175), Monoclonal and Polyclonal Antibodies Research(171)

Publications1.1k total

Immunogenicity of mRNA COVID-19 vaccine with either simultaneous or sequentially administered inactivated influenza vaccines: a randomized clinical trial
Vaccine·2025Open Access
Contemporary HIV-1 envelope pseudovirus panels for detecting and assessing B cell lineages with broadly neutralizing antibody potential
2025Open Access
HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial
Nature Communications·2025Open Access
Immunogenicity of JN.1- and KP.2-Encoding mRNA COVID-19 Vaccines Against JN.1 Subvariants in Adult Participants
Open Forum Infectious Diseases·2025· 1 citedOpen Access
Differences in neutralization susceptibility between clade C HIV viruses from breastmilk versus contemporaneous circulating viruses from sexually acquired infections
2025Open Access
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans
Cell·2025Open Access
Mechanisms of early-life immunity associated with induction of heterologous HIV-1 neutralizing antibodies 9283
The Journal of Immunology·2025Open Access
VRC01 Selects Rare HIV Escape Mutations After Acquisition in Antibody-Mediated Prevention Trials
2025· 1 citedOpen Access
HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques
Nature Communications·2025Open Access
Stable Latent HIV Infection and Low-level Viremia Despite Treatment With the Broadly Neutralizing Antibody VRC07-523LS and the Latency Reversal Agent Vorinostat
UNC Libraries·2025Open Access
Neutralizing antibody responses over time in a demographically and clinically diverse cohort of individuals recovered from SARS-CoV-2 acquisition in Africa: A cohort study
PLOS Global Public Health·2025Open Access
Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques
npj Vaccines·2025Open Access
Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial
Science Translational Medicine·2025· 13 citedOpen Access
Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials
2025· 1 citedOpen Access
Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates
Science Translational Medicine·2025· 1 cited
Germline-targeting HIV Envelope SOSIP immunization more frequently elicits broadly-neutralizing antibody precursor responses in infant compared to juvenile rhesus macaques
2025Open Access
Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-like antibodies
PLoS Pathogens·2025Open Access
Safety, pharmacokinetics, and neutralisation activity of PGDM1400LS, a V2 specific HIV-1 broadly neutralising antibody, infused intravenously or subcutaneously in people without HIV-1 in the USA (HVTN 140/HPTN 101 part A): a first-in-human, phase 1 randomised trial
The Lancet HIV·2025· 3 cited
Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans
Science·2025· 30 citedOpen Access
Precise targeting of HIV broadly neutralizing antibody precursors in humans
Science·2025· 22 citedOpen Access
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Frequent Co-authors

John R. Mascola(17), Barton F. Haynes(13), Bette Korber(12), Georgia D. Tomaras(12), Peter B. Gilbert(9), Michael S. Seaman(9), Celia C. LaBranche(7), S. Munir Alam(7), Charlene McDanal(6), Norman L. Letvin(6), Beatrice H. Hahn(6), Hua-Xin Liao(6), Guido Ferrari(6), Punnee Pitisuttithum(6), Nelson L. Michael(6), Mark G. Lewis(6), Robert Parks(6), Gary J. Nabel(6), M. Anthony Moody(6), Jörn E. Schmitz(5)