Michael S. Seaman

National Health Laboratory Service — South Africa

Immunology and Microbiology · Life Sciences

103h-index41.5kcitations422works8.42yr avg
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Research Topics

HIV Research and Treatment(327), Immune Cell Function and Interaction(138), Monoclonal and Polyclonal Antibodies Research(119), HIV/AIDS drug development and treatment(90), T-cell and B-cell Immunology(59)

Publications421 total

Host proteins associated with strong neutralizing SARS-CoV-2 antibody responses in a South African cohort
Communications Medicine·2026Open Access
B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing
2026Open Access
Minor SHIV variants abrogate protective efficacy of broadly neutralizing antibodies in rhesus macaques
Nature Communications·2025Open Access
HIV Molecular Immunology 2025
2025· 38 cited
Contemporary HIV-1 envelope pseudovirus panels for detecting and assessing B cell lineages with broadly neutralizing antibody potential
2025Open Access
Effects and mechanisms of monoclonal and polyclonal human antibodies in protection of humanized mice from HIV-1 challenge
2025Open Access
Enhanced HIV-1 Control After Antibody Therapy is Associated with Autologous Antibodies and Reservoir Clearance in the RIO trial
2025· 2 citedOpen Access
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans
Cell·2025Open Access
Mechanisms of early-life immunity associated with induction of heterologous HIV-1 neutralizing antibodies 9283
The Journal of Immunology·2025Open Access
Hydrogel formulations for sustained-release of broadly neutralizing antibodies
Journal of Controlled Release·2025
Engineering HIV antibodies with enhanced breadth and potency of neutralization through multistate affinity maturation
2025Open Access
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy
Nature Immunology·2025· 2 citedOpen Access
Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design
2025· 1 citedOpen Access
Vaccine Elicitation of HIV-1 Neutralizing Antibodies Against Both V2 Apex and Fusion Peptide in Rhesus Macaques
2025Open Access
Exceptionally broad HIV-1 neutralization via bispecific antibody–mediated prepositioning
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
Identification of a broad and potent V3 glycan site bNAb targeting an N332 <sub>gp120</sub> glycan-independent epitope
2025· 2 citedOpen Access
Profiling a large HIV-1 elite neutralizer cohort reveals remarkable CD4bs bNAb for HIV-1 prevention and therapy
2025Open Access
Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies
The Journal of Experimental Medicine·2025· 5 citedOpen Access
Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques
Cell Reports·2025· 1 citedOpen Access
Engineering Sustained-Release Broadly Neutralizing Antibody Formulations
2025Open Access
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Frequent Co-authors

Michel C. Nussenzweig(24), Florian Klein(17), Pamela J. Björkman(13), Johannes F. Scheid(11), Hugo Mouquet(11), Dan H. Barouch(10), John R. Mascola(10), Thiago Y. Oliveira(9), David C. Montefiori(9), Bruce D. Walker(8), Anthony P. West(8), Lilian Nogueira(7), Dennis R. Burton(6), Marina Caskey(6), Jinyan Liu(6), Peter Abbink(6), Peter D. Kwong(5), Galit Alter(5), John Pietzsch(5), Jeffrey V. Ravetch(5)