Thomas W. Powers

Pfizer (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index2.5kcitations56works1.12yr avg
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Research Topics

Virus-based gene therapy research(13), Glycosylation and Glycoproteins Research(11), Advanced Proteomics Techniques and Applications(7), Mass Spectrometry Techniques and Applications(7), CRISPR and Genetic Engineering(6)

Publications56 total

Does radial shockwave therapy lead to immediate improvements in pain in people with insertional Achilles tendinopathy? A randomised controlled trial
Clinical Rehabilitation·2025Open Access
Development and implementation of an LC-MS-based multi-attribute method for adeno-associated virus
Molecular Therapy — Methods & Clinical Development·2025· 1 citedOpen Access
pH-gradient cation exchange purification of IgG2 disulfide isoforms
Journal of Chromatography B·2025
Double-stranded RNA sequencing via RNase III E38A digestion followed by HPLC-MS/MS analysis
Journal of Pharmaceutical Sciences·2025
Characterization of intact mRNA-based therapeutics by charge detection mass spectrometry and mass photometry
Molecular Therapy — Methods & Clinical Development·2025· 5 citedOpen Access
Enabling icIEF Peak Identification of AAV Capsid Proteins by Fractionation on MauriceFlex and Subsequent Analysis by LC–MS
Electrophoresis·2025· 3 citedOpen Access
Interlaboratory Measurement of Adeno-Associated Virus: Comparative Quantification of Full and Empty Capsids
Human Gene Therapy·2024
Implementing a robust platform analytical procedure for measuring adeno-associated virus vector genome titer
Molecular Therapy — Methods & Clinical Development·2024Open Access
Manufacturing, Analytical, and Process Comparability Challenges for Recombinant Adeno-Associated Virus (rAAV) Gene Therapy
2024· 1 cited
Development of an icIEF assay for monitoring AAV capsid proteins and application to gene therapy products
Molecular Therapy — Methods & Clinical Development·2023· 17 citedOpen Access
Analysis of AAV-Extracted DNA by Charge Detection Mass Spectrometry Reveals Genome Truncations
Analytical Chemistry·2023· 38 cited
Attribute Analytics Performance Metrics from the MAM Consortium Interlaboratory Study
Journal of the American Society for Mass Spectrometry·2022· 14 citedOpen Access
Identification of Recombinant Chimpanzee Adenovirus C68 Degradation Products Detected by AEX-HPLC
Frontiers in Bioengineering and Biotechnology·2022Open Access
Assessment of genome packaging in AAVs using Orbitrap-based charge-detection mass spectrometry
Molecular Therapy — Methods & Clinical Development·2021· 50 citedOpen Access
Characterization of Recombinant Chimpanzee Adenovirus C68 Low and High-Density Particles: Impact on Determination of Viral Particle Titer
Frontiers in Bioengineering and Biotechnology·2021· 7 citedOpen Access
Assessment of genome packaging in AAVs using Orbitrap-based charge detection mass spectrometry
2021· 6 citedOpen Access
Comparison of analytical techniques to quantitate the capsid content of adeno-associated viral vectors
Molecular Therapy — Methods & Clinical Development·2021· 113 citedOpen Access
Quantitative analysis of genome packaging in recombinant AAV vectors by charge detection mass spectrometry
Molecular Therapy — Methods & Clinical Development·2021· 76 citedOpen Access
Adeno-associated virus capsid assembly is divergent and stochastic
Nature Communications·2021· 199 citedOpen Access
New Peak Detection Performance Metrics from the MAM Consortium Interlaboratory Study
Journal of the American Society for Mass Spectrometry·2021· 39 citedOpen Access
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Frequent Co-authors

Richard R. Drake(16), Anand S. Mehta(10), Olga Friese(8), E. Ellen Jones(6), John A. Goodno(6), Dean A. Troyer(5), Albert J. R. Heck(5), Herbert A. Runnels(5), Tobias P. Wörner(4), Joost Snijder(4), Peggi M. Angel(4), Martin F. Jarrold(4), Lauren F. Barnes(4), Thomas F. Lerch(4), Benjamin A. Neely(3), Brian B. Haab(3), Courtney D.K. Sloan(3), Verne D. Harris(3), Raymond S. Lance(3), Benjamin E. Draper(3)