Tracy M. Saxton

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index2.3kcitations15works0.02yr avg
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Research Topics

Protein Tyrosine Phosphatases(8), Protein Kinase Regulation and GTPase Signaling(5), PI3K/AKT/mTOR signaling in cancer(3), Cell death mechanisms and regulation(2), Cancer-related Molecular Pathways(2)

Publications15 total

Tony Pawson: In Memoriam
Developmental Cell·2013Open Access
Tony Pawson: In Memoriam
Neuron·2013Open Access
Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis
Current Biology·2001· 55 citedOpen Access
The Mammalian ShcB and ShcC Phosphotyrosine Docking Proteins Function in the Maturation of Sensory and Sympathetic Neurons
Neuron·2000· 109 citedOpen Access
The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development
Nature Genetics·2000· 125 cited
Signaling Networks—Do All Roads Lead to the Same Genes?
Cell·1999· 142 citedOpen Access
Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2
Molecular and Cellular Biology·1999· 210 citedOpen Access
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2
Proceedings of the National Academy of Sciences·1999· 89 citedOpen Access
Shp2 tyrosine phosphatase is required for multiple morphogenetic events during murine development
Library and Archives Canada (Government of Canada)·1999
Signaling Networks— Minireview Do All Roads Lead to the Same Genes?
1999
Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation
Cell·1998· 378 citedOpen Access
Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2
The EMBO Journal·1997· 474 citedOpen Access
Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System
Cell·1996· 534 citedOpen Access
Activation and serine phosphorylation of the p56 <i>lck</i> protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes.
The Journal of Immunology·1994· 30 cited
B cell antigen receptor cross-linking induces phosphorylation of the p21 <i>ras</i> oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein.
The Journal of Immunology·1994· 166 cited

Frequent Co-authors

Tony Pawson(9), Mark Henkemeyer(4), Ryuichi Sakai(3), Jeffrey T. Henderson(2), Alec M. Cheng(2), Sarang Kulkarni(2), James C. Cross(2), Inge van Oostveen(2), R Aebersold(2), Michael R. Gold(2), Donata Orioli(1), John Roder(1), Rüdiger Klein(1), Stéphan Gasca(1), Randy Shen(1), Derrick J. Rossi(1), Fouad Shalaby(1), Gen‐Sheng Feng(1), Geraldine Mbamalu(1), Wolfgang F. Vogel(1)