Georg C. Terstappen

Cambrian Innovation (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

38h-index5.8kcitations101works0.02yr avg
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Research Topics

Ion channel regulation and function(17), Nicotinic Acetylcholine Receptors Study(17), Neuroscience and Neuropharmacology Research(15), Receptor Mechanisms and Signaling(13), Computational Drug Discovery Methods(10)

Publications101 total

Challenges in developing Geroscience trials
Nature Communications·2023· 70 citedOpen Access
Phenotypic screen-based discovery of a small molecule that can increase adult neurogenesis and improve memory
2023· 1 citedOpen Access
A call for better understanding of target engagement in Tau antibody development
Drug Discovery Today·2022· 13 cited
A tubulin binding molecule drives differentiation of acute myeloid leukemia cells
iScience·2022· 7 citedOpen Access
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
Pharmaceutical Research·2022· 135 citedOpen Access
A novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells
2021· 2 citedOpen Access
Strategies for delivering therapeutics across the blood–brain barrier
Nature Reviews Drug Discovery·2021· 1.0k cited
Differentiation of Human Induced Pluripotent Stem Cells (hiPSC) into Endothelial-Type Cells and Establishment of an In Vitro Blood-Brain Barrier Model
Methods in molecular biology·2021· 9 cited
Trafficking of JC virus-like particles across the blood–brain barrier
Nanoscale Advances·2021· 22 citedOpen Access
Combining experimental strategies for successful target deconvolution
Drug Discovery Today·2020· 33 cited
Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs
Neuroscience Bulletin·2019· 38 citedOpen Access
Generating Human iPSC-Derived Astrocytes with Chemically Defined Medium for In Vitro Disease Modeling
Methods in molecular biology·2019· 8 cited
Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study
Stem Cell Reports·2018· 168 citedOpen Access
Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems
Drug Discovery Today·2018· 68 cited
Drug Distribution into Peripheral Nerve
Journal of Pharmacology and Experimental Therapeutics·2018· 40 cited
Quantitative Algorithm-Based Paired Imaging Measurement for Antibody-Triggered Endocytosis in Cultured Cells
SLAS DISCOVERY·2018· 1 citedOpen Access
Brain delivery research in public-private partnerships: The IMI-JU COMPACT consortium as an example
Neuropharmacology·2016· 1 cited
Label-free detection of small-molecule binding to a GPCR in the membrane environment
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics·2015· 21 cited
Targeting mutant huntingtin for the development of disease-modifying therapy
Drug Discovery Today·2012· 16 cited
Development and Validation of a Fluorescence-Based HTS Assay for the Identification of P/Q-Type Calcium Channel Blockers
Combinatorial Chemistry & High Throughput Screening·2012· 10 cited
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Frequent Co-authors

Andrea Caricasole(15), Renza Roncarati(13), G. Gaviraghi(7), Roberto Raggiaschi(6), Ferdinando Nicoletti(6), Agata Copani(5), Carla Scali(5), Marco Gianfriddo(5), John Dunlop(5), Stefano Gotta(5), Wandong Zhang(4), Filippo Caraci(4), Alessandra Caruso(4), Hendrick Bothmann(4), Axel H. Meyer(3), Luisa Iacovelli(3), Scott Summerfield(3), Enrica Diodato(3), Giuseppe Pollio(3), Brian Jow(3)